60750-28-9Relevant academic research and scientific papers
Highly regioselective addition of organozinc reagents to 2-Oxo-1,2-dihydropyrimidine-5-carboxylates activated by BF3· OEt2: Synthesis of 2-Oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylates
Singh, Kamaljit,Chopra, Rakesh
, p. 6124 - 6129 (2013/09/24)
The incorporation of alkyl as well as phenyl groups at C-4, a key position of 2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylates, responsible for antagonist/agonist switching of the calcium channel blocking activity of these compounds, has been achieved by the addition of organozinc reagents to the corresponding 2-oxo-1,2-dihydropyrimidine-5-carboxylate derivatives catalysed by BF3OEt2. An efficacious diversification of the key C-4 position of 2-oxo-1,2-dihydropyrimidine-5-carboxylates has been achieved through the addition of organozinc reagents.
Expedient Synthesis of Biginelli-Type Dihydropyrimidinones Using α-(Benzotriazolyl)alkyl Urea Derivatives
Abdel-Fattah, Ashraf A. A.
, p. 2358 - 2362 (2007/10/03)
Reaction of readily available α-(benzotriazolyl)alkyl urea derivatives (derived from aromatic, heteroaromatic, and aliphatic aldehydes) with β-keto esters resulted in 3,4-dihydropyrimidin-2(1H)-ones in good to excellent yields.
