60751-03-3Relevant articles and documents
The Difluoromethyl Group as a Masked Nucleophile: A Lewis Acid/Base Approach
Geri, Jacob B.,Wade Wolfe, Michael M.,Szymczak, Nathaniel K.
, p. 9404 - 9408 (2018)
The difluoromethyl group (R-CF2H) imparts desirable pharmacokinetic properties to drug molecules and is commonly targeted as a terminal functional group that is not amenable to further modification. Deprotonation of widely available Ar-CF2
Palladium-catalyzed sonogashira reaction for the synthesis of arylalkynecarboxylic acids from aryl bromides at low temperature
Park, Kyungho,You, Jung-Min,Jeon, Seungwon,Lee, Sunwoo
, p. 1973 - 1978 (2013/05/09)
A variety of aryl bromides were coupled with propiolic acid in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) and catalyst Pd(PPh 3)4 to afford the corresponding arylalkynecarboxylic acids in good yields at low temperature. This method showed good tolerance toward functional groups such as alkoxy, ketone, ester, aldehyde, cyano, nitro, and hydroxy. Under these conditions, propiolic acid showed higher reactivity than any other compound containing terminal alkyne groups. According to the mechanistic studies, the key reaction step for the high reactivity of propiolic acid might be ligand exchange between the acetylide and bromide at palladium, and/or reductive elimination, but not the oxidative addition step. A variety of aryl bromides were coupled with propiolic acid in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) and catalyst Pd(PPh3) 4 to afford the corresponding arylpropiolic acids in good yields at low temperature.