607692-31-9

Upstream product

• 457959-68-1 1-methyl-3-(methylamino)-1H-pyrrole-2,5-dione 
• 540-23-8 p-toluidine hydrochloride 
• 74-89-5 methylamine 
• 87748-33-2 methyl 3-carbomethoxy-3-(4'-methylphenyl)amino-2-propenoate 
• 106-49-0 p-toluidine 
• 762-42-5 dimethyl acetylenedicarboxylate 

Downstream Products

• 1613024-43-3 3-benzyl-6-methyl-1-(p-tolyl)-1,2,3,4-tetrahydro-6H-pyrrolo[3,4-d]pyrimidine-5,7-dione 
• 1613024-44-4 3-cyclohexyl-6-methyl-1-(p-tolyl)-1,2,3,4-tetrahydro-6H-pyrrolo[3,4-d]pyrimidine-5,7-dione 

Relevant academic research and scientific papers

An Efficient Synthesis of Spiropyrroloquinolines by the Domino Reaction of α-Dicarbonyl Compounds and Anilinosuccinimides

A domino annulation reaction of various α-dicarbonyl compounds with anilinosuccinimides takes place with Br?nsted-acid catalysis under microwave irradiation to give functionalized spiropyrroloquinolines. The reaction involves activation of the ortho hydrogen of the different aniline derivatives.

Synthesis of fused pyrrolo[3,4-d]tetrahydropyrimidine derivatives by proline-catalyzed multicomponent reaction

Novel proline-catalyzed multicomponent reactions (MCRs) for the synthesis of fused pyrrolo[3,4-d]tetrahydropyrimidines 7 and 9 with different substituted patterns have been developed, which provide rapid access to a library of compounds 7 and 9 in medium to excellent yields, by using N-methyl-α- aryl(alkyl)aminomaleimides, amines, and aldehydes as reactants. The catalyst and the ratio of reactants were found to have significant impact on these reactions, and a reasonable mechanism was also proposed.

Synthesis of 1-alkyl-3-arylamino-pyrrole-2,5-diones

Reaction of 1-alkyl-3-alkylaminopyrrole-2,5-diones with primary arylamine hydrochlorides in methanol or DMSO gives 1-alkyl-3-arylaminopyrrole-2,5-diones which could also be obtained from the reaction of arylaminofumarates with primary aliphatic amines.