60787-03-3

Upstream product

• 93288-84-7 1-(2-iodobenzoyl)-4-methylpiperazine hydrochloride 
• 109-01-3 1-methyl-piperazine 
• 88-67-5 2-Iodobenzoic acid 
• 609-67-6 2-Iodobenzoyl chloride 

Downstream Products

• 93288-95-0 1-methyl-4-<2-(2-hydroxymethylphenylthio)benzoyl>piperazine 
• 93288-93-8 1-methyl-4-<2-(4-chlorphenylthio)benzoyl>piperazine 
• 93288-89-2 1-methyl-4-<2-(2-methylphenylthio)benzoyl>piperazine 
• 64465-87-8 1-methyl-4-<2-(2-hydroxymethylphenylthio)benzyl>piperazine 
• 93288-91-6 1-methyl-4-<2-(4-methylphenylthio)benzoyl>piperazine 
• 93288-87-0 1-methyl-4-<2-(phenylthio)benzoyl>piperazine 

Relevant academic research and scientific papers

Direct Reductive Cyclocondensation of the Nitro Group with the Amido Group: Key Role of the Iminophosphorane Intermediate in the Synthesis of 1,4-Dibenzodiazepine Derivatives

A class of dialkylamino-substituted dibenzodiazepines and their hetero analogues was synthesized by the intramolecular aza-Wittig condensation of the amido group with iminophosphoranes. The one-pot, two-step procedure includes reductive synthesis of the intermediate iminophosphoranes from the corresponding nitroamides and tributylphosphine.

1--4-METHYLPIPERAZINE AND RELATED COMPOUNDS AS POTENTIAL ANTIDEPRESSANTS: SYNTHESIS AND PHARMACOLOGICAL SCREENING

Heating of 1-(2-iodobenzoyl)-4-methylpiperazine (II) with thiophenol and its 2-methyl, 4-methyl, 4-chloro and 2-hydroxymethyl derivatives in dimethylformamide in the presence of potassium carbonate, copper and cuprous iodide gave the piperazides IV -VIII;