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6079-88-5

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6079-88-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 6079-88-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,0,7 and 9 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 6079-88:
(6*6)+(5*0)+(4*7)+(3*9)+(2*8)+(1*8)=115
115 % 10 = 5
So 6079-88-5 is a valid CAS Registry Number.

6079-88-5Downstream Products

6079-88-5Relevant articles and documents

Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases

Rose, Nathan R.,Woon, Esther C. Y.,Tumber, Anthony,Walport, Louise J.,Chowdhury, Rasheduzzaman,Li, Xuan Shirley,King, Oliver N. F.,Lejeune, Clarisse,Ng, Stanley S.,Krojer, Tobias,Chan, Mun Chiang,Rydzik, Anna M.,Hopkinson, Richard J.,Che, Ka Hing,Daniel, Michelle,Strain-Damerell, Claire,Gileadi, Carina,Kochan, Grazyna,Leung, Ivanhoe K. H.,Dunford, James,Yeoh, Kar Kheng,Ratcliffe, Peter J.,Burgess-Brown, Nicola,Von Delft, Frank,Muller, Susanne,Marsden, Brian,Brennan, Paul E.,McDonough, Michael A.,Oppermann, Udo,Klose, Robert J.,Schofield, Christopher J.,Kawamura, Akane

supporting information; experimental part, p. 6639 - 6643 (2012/09/22)

The JmjC oxygenases catalyze the N-demethylation of Nε- methyl lysine residues in histones and are current therapeutic targets. A set of human 2-oxoglutarate analogues were screened using a unified assay platform for JmjC demethylases and related oxygenases. Results led to the finding that daminozide (N-(dimethylamino)succinamic acid, 160 Da), a plant growth regulator, selectively inhibits the KDM2/7 JmjC subfamily. Kinetic and crystallographic studies reveal that daminozide chelates the active site metal via its hydrazide carbonyl and dimethylamino groups.

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