60796-64-7

Usage

Uses

Used in Pharmaceutical Applications:
6-Hydroxy-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b']dipyran-2-one is used as a therapeutic agent for its anti-inflammatory properties, helping to reduce inflammation in various conditions.
Used in Anticancer Applications:
In the field of oncology, 6-Hydroxy-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b']dipyran-2-one is utilized as an anti-tumor agent, targeting cancer cells and potentially inhibiting their growth and proliferation.
Used in Immunomodulation:
6-Hydroxy-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b']dipyran-2-one serves as an immune-modulating agent, capable of influencing the immune system's response to various stimuli, which can be beneficial in treating autoimmune diseases or enhancing immune responses against infections.
Used in Alzheimer's Disease Treatment:
6-Hydroxy-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b']dipyran-2-one is being explored as a potential treatment for Alzheimer's disease, leveraging its neuroprotective and cognitive-enhancing properties to mitigate the effects of the condition.
Used in Research and Development:
In the scientific community, 6-Hydroxy-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b']dipyran-2-one is used as a subject of study for its unique chemical structure and potential applications in drug discovery and development, providing insights into new therapeutic approaches and chemical synthesis techniques.

Upstream product

• 305-01-1 aesculetin 
• 1740-74-5 1,1-diethoxy-3-methyl-2-butene 
• 92-61-5 7-hydroxy-6-methoxy-2H-1-benzopyran-2-one 
• 1111-97-3 3-chloro-3-methylbut-1-yne 

Relevant academic research and scientific papers

One-pot Synthesis of Fused Dipyranocoumarins from Dihydroxycoumarins and Propargyl Chlorides under Microwave Irradiation

Dipetalolactone and 4-methyldipetalolactone are prepared in excellent yield by a one-pot tandem propargylation/Claisen rearrangement/cyclization reaction of the corresponding 5,7-dihydroxycoumarins with 3-chloro-3-methylbut-1-yne in the presence of Cs2CO3 under microwave irradiation. The analogous reactions of propargyl chloride with esculetins or 5,7-dihydroxycoumarins led to dipropargyloxy derivatives. The later by treatment with gold nanoparticles supported on TiO2 or BF3.Et2O in N,N-dimethylformamide (DMF) under microwave irradiation resulted in very good to excellent yield to the corresponding fused dipyranocoumarins. The reactions of esculetins with 3-chloro-3-methylbut-1-yne gave mainly exomethylene fused dioxino[g]coumarins.

Synthesis and evaluation of substituted 8,8-dimethyl-8H-pyrano[2,3-f]chromen-2-one derivatives as vasorelaxing agents

A series of substituted 8,8-dimethyl-8H-pyrano[2,3-f]chromen-2-ones (chromeno-coumarin hybrids) was synthesized from scopoletin (11) as vasorelaxing agents. The synthesized compounds 21a-f, 22, 23a-e and scopoletin (11) were evaluated for vasorelaxation in endothelium intact rat main mesenteric artery (MMA). Compounds 11, 21a, 21c-f and 22 showed significant vasorelaxation in precontracted MMA within the range of EC50 value 1.58–5.02 μM. These derivatives presented 29.40–70.89 fold increased sensitivity for experimental tissue compared to scopoletin (11), the parent molecule. Among others, 22 was found to be the most active compound which had EC50 1.58 μM with 70.89 fold increased sensitivity. The mechanistic evaluation of 22 showed that it exerted vasorelaxation through Ca2+-activated K+ (BKca) channel and the effect was endothelium-independent.