60798-13-2

Basic information

• Product Name: 3H-Pyrazol-3-one, 2-(4-chlorophenyl)-2,4-dihydro-5-phenyl-
• CAS NO: 60798-13-2
• Molecular Formula: C15H11ClN2O
• Molecular Weight: 270.718
• Mol File: 60798-13-2.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: 3H-Pyrazol-3-one, 2-(4-chlorophenyl)-2,4-dihydro-5-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 3H-Pyrazol-3-one, 2-(4-chlorophenyl)-2,4-dihydro-5-phenyl-(60798-13-2)
• EPA Substance Registry System: 3H-Pyrazol-3-one, 2-(4-chlorophenyl)-2,4-dihydro-5-phenyl-(60798-13-2)

Safety Data

• Hazardous Substances Data: 60798-13-2(Hazardous Substances Data)

Upstream product

• 98-80-6 phenylboronic acid 
• 1073-70-7 4-chlorophenylhydrazine hydrochloride 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 1073-69-4 N-4-chlorophenylhydrazine 

Downstream Products

• 87277-65-4 2-(4-Chloro-phenyl)-4-isopropylidene-5-phenyl-2,4-dihydro-pyrazol-3-one 
• 103897-02-5 2-(4'-chloro-phenyl)-4-cycloheptyl-5-phenyl-2,4-dihydro-3H-pyrazol-3-one 
• 1220111-54-5 2-(4-chlorophenyl)-4-[(dimethylamino)methylidene]-5-phe-nyl-2,4-dihydro-3H-pyrazol-3-one 
• 1257975-94-2 3-phenyl-1-(4-chlorophenyl)-4-(4-chlorobenzylidene)pyrazol-5(4H)-one 
• 1257975-98-6 3-phenyl-1-(4-chlorophenyl)-4-(4-acetamidobenzylidene)pyrazol-5(4H)-one 
• 1257975-92-0 4-benzylidene-2-(4-chlorophenyl)-5-phenyl-2,4-dihydro-3H-pyrazol-3-one 
• 1257976-02-5 3-phenyl-1-(4-chlorophenyl)-4-(4-hydroxybenzylidene)pyrazol-5(4H)-one 
• 1257976-00-3 3-phenyl-1-(4-chlorophenyl)-4-(4-methoxybenzylidene)pyrazol-5(4H)-one 
• 1498334-93-2 1-(4-chlorophenyl)-5-methoxy-3-phenyl-1H-pyrazole 
• 1498334-94-3 2-(4-chlorophenyl)-1-methyl-5-phenyl-1H-pyrazol-3(2H)-one 
• 1498334-97-6 1-(4-chlorophenyl)-4-((dimethylamino)methyl)-3-phenyl-1H-pyrazol-5(4H)-one 
• 1498335-01-5 2-(1-(4-chlorophenyl)-5-oxo-3-phenyl-4,5-dihydro-1H-pyrazol-4-yl) acetonitrile 
• 1498335-04-8 2-(1-(4-chlorophenyl)-5-oxo-3-phenyl-4,5-dihydro-1H-pyrazol-4-yl)acetic acid 
• 1498335-07-1 methyl 2-(1-(4-chlorophenyl)-5-oxo-3-phenyl-4,5-dihydro-1H-pyrazol-4-yl)acetate 

Relevant articles and documents

Synthesis of Tetrasubstituted Pyrazoles from Substituted Hydrazines and β-Keto Esters

Herein we report the synthesis of tetrasubstituted pyrazoles from simple hydrazines and β-keto esters under mild, basic conditions. This reaction enables the selective synthesis of pyrazolones, alkoxypyrazoles, and tetrasubstituted pyrazoles for a large v

Targeting fungal virulence factor by small molecules: Structure-based discovery of novel secreted aspartic protease 2 (SAP2) inhibitors

Secreted aspartic protease 2 (SAP2), a kind of virulence factor, is an emerging new antifungal target. Using docking-based virtual screening and structure-based inhibitor design, a series of novel SAP2 inhibitors were successfully identified. Among them, indolone derivative 24a showed potent SAP2 inhibitory activity (IC50 = 0.92 μM). It blocked fungi biofilm and hypha formation by down-regulating the expression of genes SAP2, ECE1, ALS3 and EFG1. As a virulence factor inhibitor, compound 24a was inactive in vitro and showed potent in vivo efficacy in a murine model of invasive candidiasis. It represents a promising lead compound for the discovery of novel antifungal agents.

Asymmetric [3 + 3] Annulation of Copper-Allenylidenes with Pyrazolones: Synthesis of Chiral 1,4-Dihydropyrano[2,3- c]pyrazoles

The copper-catalyzed asymmetric [3 + 3] annulation of ethynyl benzoxazinanones with pyrazolones has been achieved, providing simple access to 1,4-dihydropyrano[2,3-c]pyrazole derivatives in moderate to excellent yields with excellent enantioselectivities (up to 99% ee). Compared with previous annulation reactions of copper-allenylidenes from ethynyl benzoxazinanones, the current reaction fused the three carbon atoms of the propargyl moiety into a heterocyclic framework.