60798-14-3Relevant academic research and scientific papers
Palladium catalysed hydrolysis-free arylation of aliphatic nitriles for the synthesis of 4-arylquinolin-2-one/pyrazolone derivatives
Krishna Reddy, Singarajanahalli Mundarinti,Prasanna Kumari, Subramaniyan,Selva Ganesan, Subramaniapillai
, (2021/08/03)
Palladium catalysed addition of arylboronic acid to the readily available 2-cyano-(N-aryl)-acetamide or ethyl-2-cyanoacetate followed by subsequent reaction transform them into the biologically significant 4-arylquinolin-2-one or pyrazolone derivatives. The reaction conditions are robust enough to prevent the hydrolysis of ester/amide moiety during arylation. In addition, the unactivated nitrile moiety in the acetonitrile also converted to the corresponding acetophenone derivative.
Regioselective N-Addition/Substitution Reaction of α-Alkylidene Pyrazolinones with Propargyl Sulfonium Salts to Construct Allylthio-Containing Pyrazolones
Shen, Shou-Jie,Du, Xiao-Li,Xu, Xiao-Li,Zhao, Ming-Gang,Liang, Jin-Yan
, p. 12520 - 12531 (2019/10/11)
The regioselective N-addition/substitution reaction between α-alkylidene pyrazolinones and propargyl sulfonium salts has been developed to construct functionalized allylthio-containing pyrazolones with moderate to excellent yields. α-Alkylidene pyrazolinones act as N-nucleophilic agents which are distinguished from reported C-nucleophilic reactions. Excellent regioselectivity, readily available starting materials, the broad range of substrates, gram-scale synthesis, and simple operation illustrate the synthetic advantages of this new reaction pathway.
X=Y-ZH Compounds as Potential 1,3-Dipoles. Part 41. Azomethine Ylide Formation from the Reactions of α-Amino Acids and Esters with Alloxan (Stecker Degradation) and with 1-Phenyl-3-methylpyrazolin-4,5-dione.
Aly, Moustafa F.,El-Nagger, Galal M.,El-Emary, Talaat I.,Grigg, Ronald,Metwally, Saoud A. M.,Sivagnanam, Sasikala
, p. 895 - 906 (2007/10/02)
In situ formation of imines from α-amino acids and alloxan or pyrazolin-4,5-diones results in decarboxylation forming azomethine ylides which can be trapped as their cycloadducts with maleimides.In the absence of maleimides alloxan gives murexide and the
