608533-81-9

Upstream product

• 2577-48-2 methyl (2S)-pyrrolidine carboxylate 
• 1079-66-9 chloro-diphenylphosphine 
• 2133-40-6 L-proline methyl ester monohydrochloride 

Downstream Products

• 61057-98-5 (S)-1-(Diphenyl-phosphinothioyl)-pyrrolidine-2-carboxylic acid 
• 444901-97-7 (R)-2-[(S)-1-(Diphenyl-phosphinothioyl)-pyrrolidin-2-yl]-4-isopropyl-4,5-dihydro-oxazole 
• 444901-99-9 (S)-2-[(S)-1-(Diphenyl-phosphinothioyl)-pyrrolidin-2-yl]-4-isopropyl-4,5-dihydro-oxazole 
• 1393821-66-3 C₂₅H₂₈N₂O₂P⁽¹⁺⁾*HO^(1-) 
• 1393821-67-4 C₂₄H₂₅N₂O₂P 
• 282088-13-5 (S)-1-(Diphenyl-phosphinothioyl)-pyrrolidine-2-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Proline-based phosphoramidite reagents for the reductive ligation of S-nitrosothiols

S-Nitrosothiols (RSNOs) have many biological implications but are rarely used in organic synthesis. In this work we report the development of proline-based phosphoramidite substrates that can effectively convert RSNOs to proline-based sulfenamides through

A proline-based phosphine template for Staudinger ligation

A proline-based phosphine template enabling a rapid Staudinger ligation of azide-containing substrates under mild conditions is reported. This reaction has a second-order rate constant of 1.12 M-1 s-1. It is expected that the proline

Two-fold amino acid-based chiral aminophosphine-oxazolines and use in asymmetric allylic alkylation

Chiral aminophosphine-oxazoline ligands derived from two different amino acids (tetrahydroisoquinoline carboxylic acid and proline) have been synthesized and examined as chiral auxiliaries in asymmetric allylic alkylation of three substrates. Stereoisomers 1a and 2a are providing the highest enantioselectivities (up to 94% ee) in the allylation of diphenylpropenyl acetate.