60868-76-0Relevant academic research and scientific papers
1H-Pyrazolo[3,4-b]pyridine inhibitors of cyclin-dependent kinases
Misra, Raj N.,Rawlins, David B.,Xiao, Hai-Yun,Shan, Weifang,Bursuker, Isia,Kellar, Kristin A.,Mulheron, Janet G.,Sack, John S.,Tokarski, John S.,Kimball, S. David,Webster, Kevin R.
, p. 1133 - 1136 (2007/10/03)
1H-Pyrazolo[3,4-b]pyridine 3 (SQ-67563) has been shown to be a potent, selective inhibitor of CDK1/CDK2 in vitro. In cells 3 acts as a cytotoxic agent with the ability to block cell cycle progression and/or induce apoptosis. The solid state structure of 3 bound to CDK2 shows 3 resides coincident with the ATP purine binding site and forms important H-bonding interactions with Leu83 on the protein backbone.
1H-pyrazolo[3,4-b]pyridine inhibitors of cyclin-dependent kinases: Highly potent 2,6-difluorophenacyl analogues
Misra, Raj N.,Xiao, Hai-Yun,Rawlins, David B.,Shan, Weifang,Kellar, Kristen A.,Mulheron, Janet G.,Sack, John S.,Tokarski, John S.,Kimball, S. David,Webster, Kevin R.
, p. 2405 - 2408 (2007/10/03)
Structure-activity studies of 1H-pyrazolo[3,4-b]pyridine 1 have resulted in the discovery of potent CDK1/CDK2 selective inhibitor 21h, BMS-265246 (CDK1/cycB IC50=6 nM, CDK2/cycE IC50=9 nM). The 2,6-difluorophenyl substitution was cri
Method for producing 1-unsubstituted pyrazolo[3,4-b]pyridine ketones
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, (2008/06/13)
A new process for the production of pyrazolo-[3,4-b]pyridine ketones which are unsubstituted in the 1-position comprises reacting a 1-furanylmethylpyrazolo[3,4-b]pyridine ketone with an inorganic strong mineral acid like sulfuric acid, phosphoric acid or polyphosphoric acid.
