60889-69-2Relevant academic research and scientific papers
Chemical protein synthesis by kinetically controlled ligation of peptide O-esters
Zheng, Ji-Shen,Cui, Hong-Kui,Fang, Ge-Min,Xi, Wei-An,Liu, Lei
scheme or table, p. 511 - 515 (2010/12/25)
(Chemical Equation Presented) Designer peptides: A large reactivity difference was observed between two peptide O-esters that can undergo peptide ligation through an situ O-to-S acyl shift. This observation allowed the designed of "one-pot" N-to-C sequential peptide fragment condensation through kinetically controlled ligation with more readily accessible peptide O-esters.
4-Alkoxy-2-hydroxybenzaldehyde (AHB): a versatile aldehyde linker for solid-phase synthesis of C-terminal modified peptides and peptidomimetics.
Okayama,Burritt,Hruby
, p. 1787 - 1790 (2007/10/03)
[reaction: see text] A new and versatile 4-alkoxy-2-hydroxybenzaldehyde (AHB) linker for solid-phase syntheses is described. Acylation of the polymer-bound secondary amine obtained from reductive amination of the aldehyde in the AHB linker showed good rea
