Clinical pharmacology and therapeutics p. 545 - 553 (2003)
Update date:2022-08-28
Topics:
Park, Jeong M
Lin, Yvonne S
Calamia, Justina C
Thummel, Kenneth E
Slattery, John T
Kalhorn, Thomas F
Carithers Jr., Robert L
Levy, Adam E
Marsh, Christopher L
Hebert, Mary F
BACKGROUND AND OBJECTIVES: Acetaminophen (INN, paracetamol) is metabolized to N-acetyl-p-benzoquinone imine (NAPQI), a hepatotoxic metabolite, predominantly by cytochrome P450 (CYP) 2E1. Alterations in drug metabolism occur after organ transplantation. Th
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