60912-31-4

Upstream product

• 6342-56-9 Pyruvic aldehyde dimethyl acetal 
• 100-46-9 benzylamine 
• 64053-76-5 N-(1,1-dimethoxypropan-2-ylidene)-1-phenylmethanamine 
• 1122570-41-5 benzylidene-(2,2-dimethoxy-1-methylethyl)amine 
• 33170-72-8 2-bromo-1,1-dimethoxypropane 

Downstream Products

• 1125-80-0 3-methylisoquinoline 
• 57390-38-2 2-amino-propionaldehyde dimethyl acetal 
• 18222-17-8 3-methyl-5-nitro-isoquinoline 
• 1221443-94-2 (R)-1-(7-chloro-2,2-bis(fluoromethyl)-chroman-4-yl)-3-(3-methylisoquinolin-5-yl)urea 
• 54410-17-2 3-methyl-isoquinolin-5-ylamine 

Relevant academic research and scientific papers

1,4-DISUBSTITUTED PYRIDAZINE DERIVATIVES AND THEIR USE FOR TREATING SMN-DEFICIENCY-RELATED CONDITIONS

The present invention provides a compound of formula IA or a pharmaceutically acceptable salt thereof; 5 (IA) a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

NOVEL COMPOUNDS

This invention relates to compounds of formula I their use as positive allosteric modulators of mGlu5 receptor activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of neurological and psychiatric disorders associated with glutamate dysfunction such as schizophrenia or cognitive decline such as dementia or cognitive impairment. A, B, X, R1, R2, R3 have meanings given in the description.

1,2,4 -TRIAZOLES AS ALLOSTERIC MODULATORS OF MGLU5 RECEPTOR ACTIVITY FOR THE TREATMENT OF SCHIZOPHRENIA OF DEMENTIA

This invention relates to compounds of formula (I) their use as positive allosteric modulators of mGlu5 receptor activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of neurological and psychiatric disorders associated with glutamate dysfunction such as schizophrenia or cognitive decline such as dementia or cognitive impairment. A, B, X, R1, R2, R3 have meanings given in the description.

Synthesis of 6-methyl-8H-dibenzo[a,g]quinolizin-8-imines via Reissert compounds

Alkylation of Reissert compounds derived from 3-methylisoquinolines with several 2-cyanobenzylbromides followed by hydrolytic cleavage provided the corresponding 1-benzyl-3-methylisoquinolines. Treatment of the latter with methylmagnesiumiodide caused cyclization to the title compounds rather than formation of 2-acetylbenzylisoquinolines.