57390-38-2

Usage

Uses

Used in Pharmaceutical Industry:
2,2-Dimethoxy-1-methylethylamine is used as a synthetic intermediate for the development of various pharmaceutical compounds. Its ability to form N-protected α-amino aldehydes, which are crucial components of peptide aldehydes with enzyme inhibitor activity, makes it a valuable asset in the synthesis of drugs like Leupeptin.
Used in Chemical Synthesis:
In the field of chemical synthesis, 2,2-dimethoxy-1-methylethylamine is used as a precursor for the preparation of amino sugars and unusual amino acids. These compounds have a wide range of applications, from biological research to the development of novel therapeutic agents.

InChI:InChI=1/C5H13NO2/c1-4(6)5(7-2)8-3/h4-5H,6H2,1-3H3

Upstream product

• 59566-61-9 2-azidopropanal dimethyl acetal 
• 6342-56-9 Pyruvic aldehyde dimethyl acetal 
• 1195046-02-6 C₂₂H₂₅NO₃ 
• 64053-76-5 N-(1,1-dimethoxypropan-2-ylidene)-1-phenylmethanamine 
• 60912-31-4 benzyl-(2,2-dimethoxy-1-methyl-ethyl)-amine 
• 33170-72-8 2-bromo-1,1-dimethoxypropane 

Downstream Products

• 49549-37-3 [7-chloro-5-(2-chloro-phenyl)-3H-benzo[e][1,4]diazepin-2-yl]-(2,2-dimethoxy-1-methyl-ethyl)-amine 
• 939822-13-6 (3,4-dimethoxybenzyl)-(2,2-dimethoxy-1-methylethyl)amine 
• 1214989-26-0 N-{3-(4-chlorophenyl)-1-[(1,1-dimethoxyethyl)amino]-3-[(2,2-dimethoxy-1-methylethyl)amino]prop-2-enylidene}-1,1-dimethoxypropan-2-aminium bromide 
• 1214989-14-6 N-[1,1,1-trifluoro-3-(4-nitrophenyl)propan-2-ylidene]-1,1-dimethoxypropan-2-amine 
• 1214989-13-5 (Z)-3,3,3-trifluoro-N-(1,1-dimethoxypropan-2-yl)-1-(4-nitrophenyl)prop-1-en-2-amine 
• 1307882-82-1 4-bromo-2-((2, 2-dimethoxyethyl)(methyl)amino) benzaldehyde 
• 1189152-72-4 methyl 10-cyclohexyl-2-methyl-4H-imidazo[1,2-a]indolo[1,2-d][1,4]benzodiazepine-7-carboxylate 
• 1122570-41-5 benzylidene-(2,2-dimethoxy-1-methylethyl)amine 
• 458530-50-2 1-(3-dimethoxypropyl-2-yl)amino-3-cyclohexenone 

Relevant academic research and scientific papers

Unequivocal synthesis of substituted thiazolo[3,2-a]benzimidazoles

An unequivocal route to individual substituted thiazolo[3,2-a]benzimidazole isomers has been developed, involving the acid-catalyzed intramolecular condensation of dialkylacetals with the sulfur atom of benzimidazole-2-thiones. Products are isolated without isomerization, in contrast to several literature methods.

1,4-DISUBSTITUTED PYRIDAZINE DERIVATIVES AND THEIR USE FOR TREATING SMN-DEFICIENCY-RELATED CONDITIONS

The present invention provides a compound of formula IA or a pharmaceutically acceptable salt thereof; 5 (IA) a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

NOVEL COMPOUNDS

This invention relates to compounds of formula I their use as positive allosteric modulators of mGlu5 receptor activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of neurological and psychiatric disorders associated with glutamate dysfunction such as schizophrenia or cognitive decline such as dementia or cognitive impairment. A, B, X, R1, R2, R3 have meanings given in the description.

1,2,4 -TRIAZOLES AS ALLOSTERIC MODULATORS OF MGLU5 RECEPTOR ACTIVITY FOR THE TREATMENT OF SCHIZOPHRENIA OF DEMENTIA

This invention relates to compounds of formula (I) their use as positive allosteric modulators of mGlu5 receptor activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of neurological and psychiatric disorders associated with glutamate dysfunction such as schizophrenia or cognitive decline such as dementia or cognitive impairment. A, B, X, R1, R2, R3 have meanings given in the description.

An efficient method for the preparation of versatile building blocks: 1-substituted 2,2-dimethoxyethylamine hydrochlorides1

A novel method for the preparation of 1-substituted 2,2-dimethoxyethylamine hydrochlorides was developed. The method includes three highly efficient steps: (1) direct use of aqueous (MeO)2CHCHO for the preparation of N,O-acetal by condensation with Betti

Process for the production of 2-imidazolones

The present invention pertains to a process for producing a 2-imidazolone from a ureidoacetal. The ureidoacetal is subjected to an acid catalyzed condensation in order to produce the 2-imidazolone. The reaction is conducted in an alcoholic solvent in order to minimize the production of a polymeric by-product.

Aryloxy benzotriazole herbicidal agents and methods for the preparation thereof

This invention is directed to certain substituted aryloxy benzotriazole compounds which are herbicidal agents. The structures of these compounds are represented by formulas I and II shown below: STR1 wherein M is C--X, N or N+ --O- ; W, X, Y and Z each independently represent hydrogen, halogen, nitro, cyano, C1 -C4 haloalkyl or C1 -C4 haloalkoxy; n is 0, 1 or 2; R is hydrogen, C1 -C4 alkyl, aryl or when taken together with R1, R and R1 may form a ring in which RR1 are represented by the structure --(CH2)m -- where m is an integer of 2, 3, 4 or 5; R1 and R2 are each independently hydrogen, C1 -C4 alkyl or when taken together R1 and R2 may form a ring in which R1 R2 are represented by the structure --(CH2)m -- where m is an integer of 2, 3, 4 or 5; R3 is cyano, STR2 CH2 OR8 or CH(OR9)2 ; Q is OH, OR4 or NR5 R6 ; A is O, NOR5, NCOR5, NNR5 R6 or NNHCONH2 ; R7 is hydrogen, C1 -C4 alkyl or aryl; R8 is hydrogen or C1 -C4 alkyl; R9 is C1 -C4 alkyl; R4 is C1 -C6 alkyl optionally interrupted by O or S or optionally substituted with C1 -C4 alkoxy, halogen, hydroxy, C3 --C6 cycloalkyl, furyl, or optionally substituted phenyl; C3 -C6 alkenyl optionally substituted with one or two C1 -C3 alkoxy, halogen, substituted phenyl or C3 -C6 cycloalkyl; C3 -C6 alkynyl optionally substituted with C1 -C4 alkoxy or halogen; C3 -C6 cycloalkyl; ammonium; C1 -C6 dialkylammonium; C1 -C6 trialkylammonium; a metal cation; or a moiety of formula STR3 R5 and R6 each independently represent hydrogen, C1 -C6 alkyl, phenyl or halophenyl; the benzotriazole N-oxide or N-methosulfate; and when R1 or R2 is C1 -C4 alkyl, the optical isomer thereof; with the proviso that when M is C--X in formula I, wherein X is hydrogen, halogen, nitro, cyano or C1 -C4 haloalkyl, the benzotriazole is substituted in the 6 position by aryloxy, n is O, R3 is STR4 and R7 is C1 -C4 alkyl, then R and R1 cannot be hydrogen or C1 -C4 alkyl. The invention is further directed to methods for the preparation of the aryloxy benzotriazole compounds.