60966-36-1

Basic information

• Product Name: 21-hydroxy-20-methylpregn-4-en-3-one
• Synonyms: 21-hydroxy-20-methylpregn-4-en-3-one;20-(Hydroxymethyl)pregna-4-ene-3-one;20-Hydroxymethylpregn-4-en-3-one;Pregn-4-en-3-one, 21-hydroxy-20-methyl-
• CAS NO: 60966-36-1
• Molecular Formula: C₂₂H₃₄O₂
• Molecular Weight: 330.50416
• EINECS: 262-543-1
• Mol File: 60966-36-1.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 464.1°C at 760 mmHg
• Flash Point: 197.5°C
• Appearance: /
• Density: 1.07g/cm³
• Vapor Pressure: 1.45E-10mmHg at 25°C
• Refractive Index: 1.546
• PKA: 14.97±0.10(Predicted)
• CAS DataBase Reference: 21-hydroxy-20-methylpregn-4-en-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 21-hydroxy-20-methylpregn-4-en-3-one(60966-36-1)
• EPA Substance Registry System: 21-hydroxy-20-methylpregn-4-en-3-one(60966-36-1)

Safety Data

• Hazardous Substances Data: 60966-36-1(Hazardous Substances Data)

Usage

Uses

21-Hydroxy-20-methylpregn-4-en-3one is an impurity of the steroid hormone, progesterone (P755900), produced by the corpus luteum and induces maturation and secretory activity of the uterine endothelium; suppresses ovulation.

InChI:InChI=1/C22H34O2/c1-14(13-23)18-6-7-19-17-5-4-15-12-16(24)8-10-21(15,2)20(17)9-11-22(18,19)3/h12,14,17-20,23H,4-11,13H2,1-3H3/t14?,17-,18+,19-,20-,21-,22+/m0/s1

Upstream product

• 24254-01-1 20β-carboxyaldehyde-4-pregnen-3-one 
• 3986-89-8 (20S)-3-oxopregn-4-ene-20-carboxaldehyde 

Downstream Products

• 57-83-0 Progesterone 
• 24377-48-8 22-(piperidin-1-yl)-23,24-dinorchola-4,20⁽²²⁾-dien-3-one 

Relevant articles and documents

Amines useful in producing pharmaceutically active CNS compounds

Disclosed are Δ9(11) -steroids (VI) and amino substituted steroids (XI) which contain an amino group attached to the terminal carbon atom of the C17 -side chain, more particularly amino steroids (Ia and Ib), aromatic steroids (II), Δ16 -steroids (IIIa and IIIb), reduced A-ring steroids (IV), Δ17(20) -steroids (Va and Vb) and Δ9(11) -steroids (VI) which are useful as pharmaceutical agents for treating a number of conditions.

Steriod 5-alpha-reductase inhibitors

Invented are substituted acrylate analogues of steroidal synthetic compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid 5-α-reductase. Also invented are intermediates used in preparing these compounds.

PHOSPHINIC ACID SUBSTITUTED STEROIDS AS INHIBITORS OF STEROID 5 ALPHA-REDUCTASE

The invention relates to 3-phosphinic acid steroidal compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid 5alpha-reductase.