74798-63-3Relevant academic research and scientific papers
An indole derivative and its application
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Paragraph 0113-0119, (2022/01/12)
The present invention relates to an indole derivative shown in formula (I-1) and its use in the preparation of a drug for the prevention and / or treatment of indications associated with the S1P receptor disorders. Indole derivatives of the present invent
Studies on Several 7-Substituted N,N-Dimethyltryptamines
Glennon, R. A.,Schubert, E.,Jacyno, J. M.,Rosecrans, J. A.
, p. 1222 - 1226 (2007/10/02)
Several 7-substituted derivatives of N,N-dimethyltryptamine (DMT) were prepared and evaluated in the rat fundus serotonin receptor assay and in a behavioral (discriminative stimulus) assay in rats.Both 7-Me- and 5-Ome-7-Me-DMT possess a higher pA2, and 5,7-(OMe)2-DMT a lower pA2, than that of DMT itself.Like DMT, all three of these compounds produce behavioral effects in rats which are similar to those of the hallucinogen 5-OMe-DMT.Although 7-Et- and 7-Br-DMT possess a higher serotonin receptor affinity than DMT, neither produce behavioral effects which parallelthose of 5-OMe-DMT.In contrast, 6-OMe-DMT and its 5-OMe derivative do not interact with the serotonin receptors in a competitive manner and are inactive in the discriminative stimulus assay.
