61034-42-2

Upstream product

• 530-93-8 1,2,3,4-tetrahydronaphthalen-2-one 
• 21403-95-2 1-(3,4-dihydronaphthalene-2-yl)pyrrolidine 
• 100-39-0 benzyl bromide 
• 100-44-7 benzyl chloride 
• 85035-87-6 1-benzyl-3,4-Δ¹-tetralin 
• 98577-49-2 1-phenylmethyl-1,2,3,4-tetrahydronaphthalen-1-ol 
• 1589-82-8 phenylmagnesium bromide 
• 301852-98-2 1-benzyl-1,2,3,4-tetrahydro-naphthalene-1,2-diol 
• 301852-61-9 1-benzyl-1,2-epoxytetralin 

Downstream Products

• 61441-15-4 1-Benzyl-tricyclo[7.4.1.0^2,7]tetradeca-2⁽⁷⁾,3,5-trien-14-ylamine 
• 133496-92-1 1-benzyl-2-tetralol 

Relevant academic research and scientific papers

Bifunctional Br?nsted Base Catalyst Enables Regio-, Diastereo-, and Enantioselective Cα-Alkylation of β-Tetralones and Related Aromatic-Ring-Fused Cycloalkanones

The catalytic asymmetric synthesis of both α-substituted and α,α-disubstituted (quaternary) β-tetralones through direct α-functionalization of the corresponding β-tetralone precursor remains elusive. A designed Br?nsted base-squaramide bifunctional catalyst promotes the conjugate addition of either unsubstituted or α-monosubstituted β-tetralones to nitroalkenes. Under these reaction conditions, not only enolization, and thus functionalization, occurs at the α-carbon atom of the β-tetralone exclusively, but adducts including all-carbon quaternary centers are also formed in highly diastereo- and enantioselective manner.

The synthesis of novel cis-α-substituted-β-aminotetralins

Teteralones were converted, in 1 to 3 steps, to α-substituted tetralones. Subsequent reductive amination with ammonium acetate/sodium cyanoborohydride gave the corresponding α-substituted-β-aminotetralins, on a multigram scale, with minimal chromatography for the entire transformation.

N-aralkylaminotetralins as ligands for the neuropeptide Y Y5 receptor

β-Aminotetralin derivatives of the formula: which are ligands for the neuropeptide Y Y5 (NPY5) receptor, methods of preparation and pharmaceutical compositions containing a β-aminotetralin derivative as the active ingredient are described. The 62 -aminotetralins are useful in the treatment of disorders and diseases associated with NPY receptor subtype Y5.

A concise synthesis of 1-substituted-2-tetralones by selective diol dehydration leading to ketone transposition

Dehydration of 1-substituted-1,2-tetralindiols with zinc iodide afforded the corresponding 2-tetralones in excellent yields. This procedure was found to be superior to the more conventional BF3-catalyzed rearrangement of 1-substituted-1,2-epoxytetralins. (C) 2000 Elsevier Science Ltd.