6104-41-2

Basic information

• Product Name: Pyrimidine, 4-methoxy- (6CI,7CI,8CI,9CI)
• Synonyms: Pyrimidine, 4-methoxy- (6CI,7CI,8CI,9CI);4-Methoxypyrimidine;Methyl 4-pyrimidinyl ether
• CAS NO: 6104-41-2
• Molecular Formula: C₅H₆N₂O
• Molecular Weight: 110.12
• Product Categories: PYRIMIDINE
• Mol File: 6104-41-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 70°C/22mmHg(lit.)
• Flash Point: 64.4 °C
• Appearance: /
• Density: 1.102g/cm³
• Vapor Pressure: 1.15mmHg at 25°C
• Refractive Index: 1.4990-1.5030
• CAS DataBase Reference: Pyrimidine, 4-methoxy- (6CI,7CI,8CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrimidine, 4-methoxy- (6CI,7CI,8CI,9CI)(6104-41-2)
• EPA Substance Registry System: Pyrimidine, 4-methoxy- (6CI,7CI,8CI,9CI)(6104-41-2)

Safety Data

• Hazardous Substances Data: 6104-41-2(Hazardous Substances Data)

Usage

General Description

Pyrimidine, 4-methoxy- (6CI,7CI,8CI,9CI) is a chemical compound with the molecular formula C5H6N2O. It is a derivative of pyrimidine with a methoxy group attached to the 4-position. Pyrimidine, 4-methoxy- (6CI,7CI,8CI,9CI) has not been extensively studied, but it is likely to exhibit similar properties to other pyrimidine derivatives. Pyrimidine compounds are important in biochemistry and pharmaceuticals, as they form the basis of several essential biomolecules, such as DNA and RNA. The addition of a methoxy group to the pyrimidine ring may alter its reactivity and biological activity, making it a potentially valuable compound for further research and development.

InChI:InChI=1/C5H6N2O/c1-8-5-2-3-6-4-7-5/h2-4H,1H3

Upstream product

• 186581-53-3 diazomethane 
• 51953-18-5 pyrimidine-4(3H)-one 
• 22536-63-6 2-chloro-4-methoxypyrimidine 
• 43212-41-5 2,4-dichloro-6-methoxypyrimidine 
• 26452-81-3 4-chloro-6-methoxy-pyrimidine 
• 57054-92-9 5-bromo-2-chloro-4-methoxypyrimidine 
• 16285-69-1 3-(formylamino)-2-thiophenecarboxylic acid methyl ester 
• 108782-92-9 4-O-(2-nitrophenyl)uridine 

Downstream Products

• 69543-97-1 4-bromo-6-methoxypyrimidine 
• 155-90-8 4-methoxypyrimidin-2-amine 
• 857042-18-3 5-[(hydroxyimino)(phenyl)methyl]-4-methoxypyrimidin-2(1H)-one 
• 18002-25-0 4-methoxy-2-pyrimidone 
• 17758-55-3 4-Methoxypyrimidine 1-oxide 
• 130532-95-5 α-(4-pyrimidyl)phenylacetonitrile 
• 344353-70-4 (4-methoxypyrimidin-2-yl)methanol 
• 22930-71-8 pyrimidin-4-ylhydrazine 
• 6104-45-6 3-methylpyrimidin-4-one 

Relevant articles and documents

Electron-deficient heteroarenium salts: An organocatalytic tool for activation of hydrogen peroxide in oxidations

A series of monosubstituted pyrimidinium and pyrazinium triflates and 3,5-disubstituted pyridinium triflates were prepared and tested as simple catalysts of oxidations with hydrogen peroxide, using sulfoxidation as a model reaction. Their catalytic efficiency strongly depends on the type of substituent and is remarkable for derivatives with an electron-withdrawing group, showing reactivity comparable to that of flavinium salts which are the prominent organocatalysts for oxygenations. Because of their high stability and good accessibility, 4-(trifluoromethyl)pyrimidinium and 3,5-dinitropyridinium triflates are the catalysts of choice and were shown to catalyze oxidation of aliphatic and aromatic sulfides to sulfoxides, giving quantitative conversions, high preparative yields and excellent chemoselectivity. The high efficiency of electron-poor heteroarenium salts is rationalized by their ability to readily form adducts with nucleophiles, as documented by low pKR+ values (pKR+ red > -0.5 V). Hydrogen peroxide adducts formed in situ during catalytic oxidation act as substrate oxidizing agents. The Gibbs free energies of oxygen transfer from these heterocyclic hydroperoxides to thioanisole, obtained by calculations at the B3LYP/6-311++g(d,p) level, showed that they are much stronger oxidizing agents than alkyl hydroperoxides and in some cases are almost comparable to derivatives of flavin hydroperoxide acting as oxidizing agents in monooxygenases.

Thienopyrimidine-based inhibitors of the Src family

Various thienopyrimidine-based analog compounds that selectively inhibit the Src family of tyrosine kinases. These compounds are thienopyrimidines and contain a hydrozone bridge created by heating a thienopyrimidine hydrazine with an aldehyde in ethanol at reflux. Such compounds are useful in the treatment of various diseases including hyperproliferative diseases, hematologic diseases, osteoporosis, neurological diseases, autoimmune diseases, allergic/immunological diseases, or viral infections.