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Upstream product

• 100-64-1 cyclohexanone-oxime 
• 1126-46-1 Methyl 4-chlorobenzoate 
• 2305-78-4 4,5,6,7-tetrahydro-2,1-benzisoxazole 
• 637-87-6 1-Chloro-4-iodobenzene 
• 38968-76-2 2-(4'-chloro)benzoylcyclohexanone 

Relevant academic research and scientific papers

Palladium-Catalyzed Direct C-H Arylation of Isoxazoles at the 5-Position

A palladium-catalyzed direct arylation of isoxazoles with aryl iodides has been achieved. The C-H bond at the 5-position is activated selectively to give coupling products in moderate to good yields. This direct arylation was applied to the synthesis of a spiro-type chiral ligand, which proved to be most effective to the palladium-catalyzed tandem cyclization of a dialkenyl alcohol.

SYNTHESIS OF ISOXAZOLE DERIVATIVES IN REACTION OF 2-HYDROXYPHENYLCARBONYL COMPOUNDS OR 1,3-DIKETONES WITH HYDROXYLAMINE-O-SULFONIC ACID

2-Hydroxybenzaldehyde 1a and 2-hydroxyacetophenone 1b react with hydroxylamine-O-sulfonic acid (HSA) yielding the corresponding oxime hydrogensulfates 2a and 2b, separated as potassium salts.These salts undergo conversion with good yields to benzisoxazole 3a and 2-methylbenzoxazole 3b, respectively.In similar reaction of 1,3-diketones, both cyclic and acyclic 1c-k with HSA, isoxazole derivatives 3c-k were obtained.

Synthesis of Isomeric Series of Aryltetrahydrobenzisoxazoles and Arylcyclopentisoxazoles

Four series of potential PAF-antagonists in which the isoxazole nucleus is condensed with a polyhydrogenated five- or six-carbon ring were prepared.The synthesis of the compounds 3-aryl-4,5,6,7-tetrahydrobenzisoxazoles 1, 3-arylcyclopentisoxazole 2,