61081-33-2

Upstream product

• 3740-52-1 2-(2-nitrophenyl)acetic acid 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 88-72-2 1-methyl-2-nitrobenzene 
• 7569-26-8 chloromethyl p-tolylsulfone 
• 98-95-3 nitrobenzene 
• 3958-60-9 2-nitrophenylmethyl bromide 
• 64-17-5 ethanol 
• 860242-12-2 (α-bromo-2-nitro-benzyl)-p-tolyl sulfone 
• 127-09-3 sodium acetate 

Downstream Products

• 860242-12-2 (α-bromo-2-nitro-benzyl)-p-tolyl sulfone 
• 104894-31-7 o-acetylamino p-tolyl sulfone 
• 211320-30-8 C₃₂H₂₈NO₂PS 
• 211320-38-6 [(E)-2-(Toluene-4-sulfonylmethyl)-phenylimino]-p-tolyl-acetonitrile 
• 211320-36-4 Phenyl-[(E)-2-(toluene-4-sulfonylmethyl)-phenylimino]-acetonitrile 
• 211320-57-9 Phenyl-[2-(toluene-4-sulfonylmethyl)-phenyl]-carbodiimide 
• 211320-24-0 C₁₄H₁₃N₃O₂S 
• 32884-82-5 3-(4-methylphenylsulfonyl)-1H-indole 
• 104894-30-6 o-aminobenzyl p-tolyl sulfone 

Relevant academic research and scientific papers

Copper-Mediated Decarboxylative Sulfonylation of Arylacetic Acids with Sodium Sulfinates

Herein, we present a copper-mediated decarboxylative sulfonylation of arylacetic acids with sodium sulfinates that provides viable access to sulfone compounds. This protocol features readily available feedstocks, simple operations, high regioselectivities, and moderate to good yields. The newly obtained products could be converted to other useful compounds. Importantly, the products and their derivatives exhibited potent antitumor activities in vitro, which were tested by MTT assay.

1-(2-Aminoethyl)-3-(arylsulfonyl)-1H-indoles as novel 5-HT6 receptor ligands

Novel 1-(2-aminoethyl)-3-(arylsulfonyl)-1H-indoles were prepared. Binding assays indicated they are 5-HT6 receptor ligands, among which N,N-dimethyl-N-{2-[3-(1-naphthylsulfonyl)-1H-indol-1-yl]ethyl}amine 8t and N-methyl-N-{2-[3-(1-naphthylsulfonyl)-1H-indol-1-yl]ethyl}amine 8u showed high affinity for 5-HT6 receptors with Ki = 3.7 and 5.7 nM, respectively. Novel 1-(2-aminoethyl)-3-(arylsulfonyl)-1H-indoles were prepared. Binding assays indicated they are 5-HT6 receptor ligands, among which N,N-dimethyl-N-{2-[3-(1-naphthylsulfonyl)-1H-indol-1-yl]ethyl}amine 8t and N-methyl-N-{2-[3-(1-naphthylsulfonyl)-1H-indol-1-yl]ethyl}amine 8u showed high affinity for 5-HT6 receptors with Ki = 3.7 and 5.7 nM, respectively.

Synthesis of 2-aryl-3-arylsulfonylindoles and 2-anilino-3- arylsulfonylindoles from 2-(arylsulfonyl)methylanilines using the aza-Wittig reaction of iminophosphoranes

2-(Arylsulfonyl)methyl-N-(triphenylphosphoranylidene)-anilines 5 were prepared starting from 2-(arylsulfonyl)-methylanilines 2. The aza-Wittig reaction of iminophosphoranes 5 with acyl cyanides gave N- [aryl(cyano)methylene]-2-(arylsulfonyl)methylanilines

Efficient synthesis of sulphones using polysorbate-80 as phase transfer catalyst

A very easy and practical method of preparing sulphones from alkyl halides has been developed using Polysorbate-80 as phase transfer catalyst.

A simple and rapid preparation of sulfones from alkyl halides using ultrasound

Appropriate alkyl halides and sodium p-toluenesulfinates react rapidly in DMF-water at room temperature under the influence of ultrasound to afford sulfones. Using this procedure a wide variety of sulfones have been prepared.

UNE NOUVELLE VOIE D'ACCES AUX INDOLES PAR CONDENSATION YLURE-AMIDE

o-Acylaminobenzylidenephosphoranes lead to indoles in good yield by an intramolecular Wittig reaction with the amide carbonyl group.Mechanistic aspects are discussed.A general method is described for the synthesis of indoles from o-nitrobenzyl bromides and o-aminobenzyl alcohols.