61081-33-2

Basic information

• Product Name: Benzene, 1-[[(4-methylphenyl)sulfonyl]methyl]-2-nitro-
• CAS NO: 61081-33-2
• Molecular Formula: C14H13NO4S
• Molecular Weight: 291.328
• Mol File: 61081-33-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Benzene, 1-[[(4-methylphenyl)sulfonyl]methyl]-2-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-[[(4-methylphenyl)sulfonyl]methyl]-2-nitro-(61081-33-2)
• EPA Substance Registry System: Benzene, 1-[[(4-methylphenyl)sulfonyl]methyl]-2-nitro-(61081-33-2)

Safety Data

• Hazardous Substances Data: 61081-33-2(Hazardous Substances Data)

Upstream product

• 88-72-2 1-methyl-2-nitrobenzene 
• 3740-52-1 2-(2-nitrophenyl)acetic acid 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 7569-26-8 chloromethyl p-tolylsulfone 
• 98-95-3 nitrobenzene 
• 3958-60-9 2-nitrophenylmethyl bromide 
• 64-17-5 ethanol 
• 860242-12-2 (α-bromo-2-nitro-benzyl)-p-tolyl sulfone 
• 127-09-3 sodium acetate 

Downstream Products

• 211320-24-0 C₁₄H₁₃N₃O₂S 
• 211320-57-9 Phenyl-[2-(toluene-4-sulfonylmethyl)-phenyl]-carbodiimide 
• 211320-36-4 Phenyl-[(E)-2-(toluene-4-sulfonylmethyl)-phenylimino]-acetonitrile 
• 211320-38-6 [(E)-2-(Toluene-4-sulfonylmethyl)-phenylimino]-p-tolyl-acetonitrile 
• 211320-30-8 C₃₂H₂₈NO₂PS 
• 104894-31-7 o-acetylamino p-tolyl sulfone 
• 32884-82-5 3-(4-methylphenylsulfonyl)-1H-indole 
• 104894-30-6 o-aminobenzyl p-tolyl sulfone 
• 860242-12-2 (α-bromo-2-nitro-benzyl)-p-tolyl sulfone 

Relevant articles and documents

Copper-Mediated Decarboxylative Sulfonylation of Arylacetic Acids with Sodium Sulfinates

Herein, we present a copper-mediated decarboxylative sulfonylation of arylacetic acids with sodium sulfinates that provides viable access to sulfone compounds. This protocol features readily available feedstocks, simple operations, high regioselectivities, and moderate to good yields. The newly obtained products could be converted to other useful compounds. Importantly, the products and their derivatives exhibited potent antitumor activities in vitro, which were tested by MTT assay.

Synthesis of 2-aryl-3-arylsulfonylindoles and 2-anilino-3- arylsulfonylindoles from 2-(arylsulfonyl)methylanilines using the aza-Wittig reaction of iminophosphoranes

2-(Arylsulfonyl)methyl-N-(triphenylphosphoranylidene)-anilines 5 were prepared starting from 2-(arylsulfonyl)-methylanilines 2. The aza-Wittig reaction of iminophosphoranes 5 with acyl cyanides gave N- [aryl(cyano)methylene]-2-(arylsulfonyl)methylanilines

A simple and rapid preparation of sulfones from alkyl halides using ultrasound

Appropriate alkyl halides and sodium p-toluenesulfinates react rapidly in DMF-water at room temperature under the influence of ultrasound to afford sulfones. Using this procedure a wide variety of sulfones have been prepared.