61085-36-7

Usage

Uses

Used in Pharmaceutical Industry:
4-Piperidinecarbonitrile, 4-(phenylamino)-1-(2-phenylethyl)is used as a building block in the synthesis of various biologically active molecules for pharmaceutical applications. Its unique chemical structure allows for the development of compounds with diverse therapeutic effects.
Used in Agrochemical Industry:
4-Piperidinecarbonitrile, 4-(phenylamino)-1-(2-phenylethyl)is also utilized in the production of agrochemicals, where it serves as an important intermediate in the synthesis of various agrochemical products. Its properties and structure contribute to the development of effective and targeted agrochemicals.
Used in Organic Synthesis:
4-Piperidinecarbonitrile, 4-(phenylamino)-1-(2-phenylethyl)is used as a versatile building block in organic synthesis for the preparation of a wide range of compounds with diverse applications. Its unique structure and properties make it suitable for the synthesis of various organic compounds, contributing to the advancement of chemical research and development.

Upstream product

• 39742-60-4 1-(2-phenylethyl)-4-piperidinone 
• 7677-24-9 trimethylsilyl cyanide 
• 62-53-3 aniline 

Downstream Products

• 1529791-03-4 1-(2-phenylethyl)-4,4-(2-phenyl-2,4-diaza-4-oxo-cyclopentane)piperidine 
• 61085-55-0 methyl 4-(phenylamino)-1-(2-phenylethyl)-4-piperidinecarboxylate 
• 61085-59-4 benzyl 4-anilino-1-(2-phenylethyl)piperidine-4-carboxylate 
• 61085-58-3 1-methylethyl 4-(phenylamino)-1-(2-phenylethyl)-4-piperidinecarboxylate 
• 61085-57-2 2-propenyl 4-(phenylamino)-1-(2-phenylethyl)-4-piperidinecarboxylate 
• 61085-56-1 4-anilino-1-phenethyl-piperidine-4-carboxylic acid ethyl ester 
• 61086-05-3 4-(N-phenylamino)-1-(2-phenylethyl)-4-piperidinylmethanol 
• 61085-40-3 4-(phenylamino)-1-(2-phenylethyl)-4-piperidinecarboxamide 

Relevant academic research and scientific papers

Nonpeptide small molecule agonist and antagonist original leads for neuropeptide FF1 and FF2 receptors

Neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R), and their endogenous ligand NPFF, are one of only several systems responsible for mediating opioid-induced hyperalgesia, tolerance, and dependence. Currently, no small molecules displaying good affinity or selectivity for either subtype have been reported, to decipher the role of NPFF2-R as it relates to opioid-mediated analgesia, for further exploration of NPFF1-R, or for medication development for either subtype. We report the first nonpeptide small molecule scaffold for NPFF1,2-R, the guanidino-piperidines, and SAR studies resulting in the discovery of a NPFF1 agonist (7b, Ki = 487 ± 117 nM), a NPFF1 antagonist (46, Ki = 81 ± 17 nM), and a NPFF2 partial antagonist (53a, Ki = 30 ± 5 nM), which serve as leads for the development of pharmacological probes and potential therapeutic agents. Testing of 46 alone was without effect in the mouse 48 °C warm-water tail-withdrawal test, but pretreatment with 46 prevented NPFF-induced hyperalgesia.

Synthesis of intermediate anilino methyl esters used in the production of synthetic opioid analgesics

An improved process or method of synthesis of carfentanil and other potent opioid analgesics of the N-alkyl 4-substituted 4-piperidinylamide class which can be used as morphine substitutes.

N-(4-piperidinyl)-N-phenylamides

Novel N-(4-piperidinyl)-N-phenylamides and -carbamates having very potent analgesic activity, methods of preparing same and useful intermediates therefor.

N-(4-piperidinyl)-N-phenylamides and -carbamates

Novel N-(4-piperidinyl)-N-phenylamides and -carbamates having very potent analgesic activity, methods of preparing same and useful intermediates therefor.