61085-55-0

Upstream product

• 67-56-1 methanol 
• 1529791-03-4 1-(2-phenylethyl)-4,4-(2-phenyl-2,4-diaza-4-oxo-cyclopentane)piperidine 
• 61085-36-7 1-phenylethyl-4-(phenylamino)piperidine-4-carbonitrile 
• 61085-40-3 4-(phenylamino)-1-(2-phenylethyl)-4-piperidinecarboxamide 
• 62-53-3 aniline 
• 39742-60-4 1-(2-phenylethyl)-4-piperidinone 
• 498-94-2 isonipecotic acid 
• 100-42-5 styrene 
• 807315-42-0 1-phenethyl-piperidine-4-carboxylic acid 
• 103-63-9 1-phenyl-2-bromoethane 
• 68-34-8 phenyl toluenesulfonamide 
• 404-24-0 2,2,2-trifluoro-N-phenylacetamide 

Downstream Products

• 59708-52-0 carfentanil 

Relevant academic research and scientific papers

Synthetic method of anesthetic analgesic drug

The invention discloses a synthetic method of an anesthetic analgesic drug. According to the synthetic method, 4-piperidinecarboxylic acid is used as a raw material and subjected to alkylation, bromination, methylation, acylation and the like to prepare the anesthetic analgesic drug. The method avoids the usage of highly toxic cyanide, so the safety and controllability of operation are improved; the method avoids an elimination reaction in reaction process, thereby accelerating reaction speed and shortening reaction time; and the method reduces reaction temperature, shortens the reaction time,and is more suitable for industrial production.

Synthesis of intermediate anilino methyl esters used in the production of synthetic opioid analgesics

An improved process or method of synthesis of carfentanil and other potent opioid analgesics of the N-alkyl 4-substituted 4-piperidinylamide class which can be used as morphine substitutes.

Synthesis of 4-anilinopiperidine methyl esters, intermediates in the production of carfentanil, sufentanil, and remifentanil

Two spirodiaza intermediates have been made and employed in the synthesis of 4-anilinopiperidine methyl esters. These intermediates can be utilized in the production of commercial synthetic analgesics carfentanil, sufentanil, and remifentanil.

N-(4-piperidinyl)-N-phenylamides

Novel N-(4-piperidinyl)-N-phenylamides and -carbamates having very potent analgesic activity, methods of preparing same and useful intermediates therefor.

N-(4-piperidinyl)-N-phenylamides and -carbamates

Novel N-(4-piperidinyl)-N-phenylamides and -carbamates having very potent analgesic activity, methods of preparing same and useful intermediates therefor.