61085-80-1

Usage

Uses

Used in Pharmaceutical Industry:
4-Piperidinecarboxylic acid, 4-(phenylamino)-, methyl ester is used as an intermediate in the synthesis of Remifentanil Ester Hydrochloride (R143515), a controlled substance and an opioid analgesic. It plays a vital role in the development of potent pain relief medications.
Additionally, it is used as an intermediate in the synthesis of isothiocyanate derivatives of carfentanils and (methoxymethyl)fentanyls, which are opioid δ receptor irreversible inhibitors. These compounds have potential applications in the treatment of various conditions, including chronic pain and addiction management.

Upstream product

• 67-56-1 methanol 
• 772283-93-9 N-phenyl-α-(4-piperidino)glycine 

Downstream Products

• 61085-60-7 methyl 4-(phenylamino)-1-(phenylmethyl)-4-piperidinecarboxylate 
• 938184-95-3 methyl 3-(4-N-aminophenyl-4-carbomethoxy-piperidino)propionate 

Relevant academic research and scientific papers

Alternate Process for Remifentanil Preparation

An alternate process for synthesizing opiate or opioid analgesics and anesthetics, and intermediates thereof is provided. In particular, a process of synthesizing synthetic opiate or opioid compounds such as, for example, remifentanil, carfentanil, sufentanil, fentanyl, and alfentanil are disclosed.

PROCESS FOR SYNTHESIZING REMIFENTANIL

A process for synthesizing remifentanil or carfentanil, as well as intermediates for use in the preparation of synthetic opiate or opioid compounds. The process comprising reacting a 4-amino 4-carbamyl piperidine with a base in a closed reaction chamber at elevated temperature and pressure to form to intermediate which may be esterified with an alcohol, alkylated, and acylated to produce a synthetic opiate or opioid compound.

N-Aryl-N-(1-L-4-piperidinyl)-arylacetamides

Novel N-aryl-N-(1-L-4-piperidinyl)arylacetamides useful as anti-arrhythmic agents, a method of treating arrhythmia which comprises the systemic administration of such compounds to warm-blooded animals and pharmaceutical compositions to be used therefor.

N-aryl-N-(1-alkyl-4-piperidinyl)-arylacetamides

Novel N-aryl-N-(1-L-4-piperidinyl)arylacetamides useful as antiarrhythmic agents, a method of treating arrhythmia which comprises the systemic administration of such compounds to warm-blooded animals and pharmaceutical compositions to be used therefor.