61153-76-2

Basic information

• Product Name: licodione
• Synonyms: licodione;1-(2,4-Dihydroxyphenyl)-3-(4-hydroxyphenyl)-1,3-propanedione
• CAS NO: 61153-76-2
• Molecular Formula: C₁₅H₁₂O₅
• Molecular Weight: 272.25
• Mol File: 61153-76-2.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 569°C at 760 mmHg
• Flash Point: 312°C
• Appearance: /
• Density: 1.416g/cm³
• Vapor Pressure: 1.5E-13mmHg at 25°C
• Refractive Index: 1.666
• PKA: 7.42±0.35(Predicted)
• CAS DataBase Reference: licodione(CAS DataBase Reference)
• NIST Chemistry Reference: licodione(61153-76-2)
• EPA Substance Registry System: licodione(61153-76-2)

Safety Data

• Hazardous Substances Data: 61153-76-2(Hazardous Substances Data)

Usage

Definition

ChEBI: A beta-diketone that is acetylacetone in which a 4-hydroxyphenyl group and a 2,4-dihydroxyphenyl group replace the two methyl groups.

InChI:InChI=1/C15H12O5/c16-10-3-1-9(2-4-10)13(18)8-15(20)12-6-5-11(17)7-14(12)19/h1-7,16-17,19H,8H2

Upstream product

• 141993-06-8 3-(4-hydroxyphenyl)-5-tributylstannylisoxazole 
• 41046-68-8 4-iodobenzene-1,3-diol 
• 1486-51-7 p-(benzyloxy)benzoic acid 
• 1486-50-6 4-(benzyloxy)benzoic acid chloride 
• 120-47-8 Ethyl 4-hydroxybenzoate 
• 76690-68-1 1-(2-hydroxy-4-benzyloxyphenyl)-3-(4-benzyloxyphenyl)-1,3-propanedione 
• 155721-20-3 5-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)isoxazole 

Downstream Products

• 75808-78-5 2'-O-methyl-licodione 

Relevant articles and documents

Synthesis of Flavones via Application of the Nitrile Oxide and the Stille Reactions

Hydroxylated and methoxylated benzaldehyde oximes have been chlorinated, dehydrohalogenated and cycloadded to tributylstannylacetylene to give 3-aryl-5-tributylstannylisoxazoles in good to excellent yields.The palladium-catalyzed coupling reaction, the so-called Stille reaction, of hindered and electron-rich 2-iodophenols and a 2-iodo-1,4-benzoquinone with 3-aryl-5-tributylstannyl-isoxazoles gave 3-aryl-5-(2-hydroxyaryl)isoxazoles in moderate to excellent yields.The coupling reaction was studied under various conditions and with various Pd(II) and Pd(0) complexes.Reduction of the 3,5-diarylisoxazoles with H2/Raney-Ni, hydrolysis and acid-catalyzed cyclisation gave flavones.The synthesis of 2-iodo-3,5-dimethoxy-1,4-benzoquinone is described.