61164-71-4

Usage

Derivative of quinoline

Quinoline is a heterocyclic compound with various pharmaceutical and industrial applications, and 2-(2-Oxo-1,2,3,4-Tetrahydroquinolin-3-Yl)Acetic Acid is derived from it.

Carboxylic acid derivative

2-(2-Oxo-1,2,3,4-Tetrahydroquinolin-3-Yl)Acetic Acid contains a carboxylic acid functional group (-COOH), which imparts acidic properties to the molecule.

Tetrahydroquinoline moiety

The presence of a tetrahydroquinoline group in the structure suggests potential biological activity and pharmacological properties.

Pharmacological properties

Tetrahydroquinolines are known to possess properties such as anti-inflammatory and analgesic effects, which may be relevant to 2-(2-Oxo-1,2,3,4-Tetrahydroquinolin-3-Yl)Acetic Acid.

Potential uses in pharmaceuticals

Due to its quinoline and tetrahydroquinoline derivatives, 2-(2-Oxo-1,2,3,4-Tetrahydroquinolin-3-Yl)Acetic Acid may have potential applications in the pharmaceutical industry, but further research is needed to determine its specific uses.

Potential uses in other industries

The compound may also have applications in other industries, but its specific uses would require further investigation and research.

Upstream product

• 7647-01-0 hydrogenchloride 
• 412027-25-9 2-oxo-2,3,4,5-tetrahydro-1H-benz[b]azepine-4-carboxylic acid ethyl ester 
• 553-03-7 3,4-dihydro-2(1H)-quinolone 
• 792122-84-0 1-[(4-methoxyphenyl)methyl]-3,4-dihydroquinolin-2-one 
• 689281-04-7 [1-(4-methoxy-benzyl)-2-oxo-1,2,3,4-tetrahydro-quinolin-3-yl]-acetic acid tert-butyl ester 

Relevant academic research and scientific papers

Identification of novel potent bicyclic peptide deformylase inhibitors

Screening of our compound collection using Staphylococcus aureus Ni-Peptide deformylase (PDF) afforded a very potent PDF inhibitor with an IC50 in the low nanomolar range but with poor antibacterial activity (MIC). Three-dimensional structural information obtained from Pseudomonas aeruginosa Ni-PDF complexed with the inhibitor suggested the synthesis of a variety of analogues that would maintain high binding affinity while attempting to improve antibacterial activity. Many of the compounds synthesized proved to be excellent PDF-Ni inhibitors and some showed increased antibacterial activity in selected strains.

Amine compounds, their production and use

The present invention provides a compound of the formula: wherein Ar represents an aromatic group which may be substituted; X represents methylene, S, SO, SO2or CO; Y represents a spacer having a main chain of 2 to 5 atoms; n represents an integer of 1 to 5; i) R1and R2each represents a hydrogen atom or a lower alkyl which may be substituted, ii) R1and R2form, taken together with the adjacent nitrogen atom, a nitrogen-containing heterocyclic ring which may be substituted, or iii) R1or R2together with —(CH2)n—N═ form, bonded to a component atom of Ring B, a spiro-ring which may be substituted; Ring A represents an aromatic ring which may be substituted; Ring B represents a 4- to 7-membered nitrogen-containing non-aromatic ring which may be further substituted by alkyl or acyl, with a proviso that X represents S, SO, SO2or CO when Ring A has as a substituent a group represented by the formula: —NHCOR11 where R11represents alkyl, alkoxyalkyl, alkylthioalkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl or a group represented by the formula: —NHR12 where R12represents alkyl, cycloalkyl, cycloalkylalkyl, aryl or arylalkyl, or a salt thereof; which has an excellent somatostatin receptor binding inhibition action.

Hypotensive agents

Optionally substituted 1-H-2,3,3a,4-Tetrahydro-2-oxopyrrolo[2,3-b]quinolines or the pharmaceutically acceptable salts thereof are compounds useful as blood platelet anti-aggregative and/or antihypertensive agents in mammals, including humans.