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Acetamide, N-(2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl)-, also known as N-(2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl)acetamide, is a chemical compound with the molecular formula C10H9NO4. It is a derivative of acetamide, featuring a 2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl group attached to the nitrogen atom. Acetamide,N-(2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl)- is characterized by its unique structure, which includes a fused ring system with a carbonyl group at positions 1 and 3, and a hydroxyl group at position 2. It is a white crystalline solid and is used in various chemical and pharmaceutical applications, such as the synthesis of pharmaceuticals and other organic compounds. Due to its specific functional groups and structural features, it exhibits unique chemical properties and reactivity, making it a valuable intermediate in organic synthesis.

6118-65-6

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6118-65-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 6118-65-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,1,1 and 8 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 6118-65:
(6*6)+(5*1)+(4*1)+(3*8)+(2*6)+(1*5)=86
86 % 10 = 6
So 6118-65-6 is a valid CAS Registry Number.
InChI:InChI=1/C10H8N2O3/c1-5(13)11-7-4-2-3-6-8(7)10(15)12-9(6)14/h2-4H,1H3,(H,11,13)(H,12,14,15)

6118-65-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name N-(1,3-dioxoisoindol-4-yl)acetamide

1.2 Other means of identification

Product number -
Other names HMS2328N10

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:6118-65-6 SDS

6118-65-6Relevant academic research and scientific papers

Chemoenzymatic synthesis of apremilast: A study using ketoreductases and lipases

Vega, Kimberly B.,Cruz, Daniel M. V.,Oliveira, Artur R. T.,Da Silva, Marcos R.,De Lemos, Telma L. G.,Oliveira, Maria C. F.,Bernardo, Ricardo D. S.,De Sousa, Jackson R.,Zanatta, Geancarlo,Nasário, Fábio D.,Marsaioli, Anita J.,De Mattos, Marcos C.

, p. 1100 - 1110 (2021/05/19)

The key step in the chemoenzymatic synthesis of apremilast was to produce the chiral alcohol (R)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanol, (R)-3. Two enzymatic approaches were evaluated to obtain (R)-3, one using ketoreductases and the other lipases. Bioreduction of 1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanone (2), using ketoreductase KRED.P2-D12, led to (R)-3 with 48% conversion and 93% enantiomeric excess (ee). Kinetic resolution of rac-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl acetate (rac-4), via hydrolysis reaction, with 20% of n-butanol, catalyzed by lipase from Aspergillus niger yielded (R)-3 with > 99% ee, 50% conversion and E-value (enantiomeric ratio) > 200. The reaction between enantiomerically pure (R)-3 and 4-acetylamino-isoindol-1,3-dione (8) afforded apremilast in 65% yield and 67% ee.

Preparation method of 3-acetyl aminophthalimide

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Paragraph 0037; 0038, (2016/10/07)

The invention relates to a preparation method of 3-acetyl aminophthalimide, comprising the following steps: dissolving 3-nitro phthalic acid in sodium hydroxide aqueous solution, then adding a reducer and a catalyst, heating to 70 to 80 DEG C, stirring and reacting for 1 to 20 hours, and recrystallizing to obtain 3-amino phthalic acid; stirring with acetic anhydride and performing reflux reaction for 1 to 10 hours to obtain N-(1,3-Dioxo-1,3-dihydro-2-benzofuran-4-yl)acetamide; dissolving the N-(1,3-Dioxo-1,3-dihydro-2-benzofuran-4-yl)acetamide in an organic solvent, adding an amino donor, and stirring and refluxing for 1 to 10 hours, thus obtaining the 3-acetyl aminophthalimide. The method is simple in operation, high in yield, short in reaction route, less in the three wastes (waste gas industrial residue), and easy for industrial production.

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