61190-11-2

Basic information

• Product Name: 2,2-diethoxy-N-(3-methoxybenzyl)ethanamine
• CAS NO: 61190-11-2
• Molecular Formula: C₁₄H₂₃NO₃
• Molecular Weight: 253.3373
• Mol File: 61190-11-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 333.6°C at 760 mmHg
• Flash Point: 143.5°C
• Density: 1.01g/cm³
• Vapor Pressure: 0.000135mmHg at 25°C
• Refractive Index: 1.491
• CAS DataBase Reference: 2,2-diethoxy-N-(3-methoxybenzyl)ethanamine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-diethoxy-N-(3-methoxybenzyl)ethanamine(61190-11-2)
• EPA Substance Registry System: 2,2-diethoxy-N-(3-methoxybenzyl)ethanamine(61190-11-2)

Safety Data

• Hazardous Substances Data: 61190-11-2(Hazardous Substances Data)

Usage

Derived from

Ethanamine

Substituents

Two ethoxy groups and a 3-methoxybenzyl group

Type of amine

Secondary amine

Usage

Commonly used in organic synthesis

Potential applications

Pharmaceutical research, as an intermediate in drug production

Role

Building block in the synthesis of more complex organic molecules

Range of uses

Potential uses in research and industry

Upstream product

• 61190-04-3 (3-methoxy-benzylidenamino)-acetaldehyde diethylacetal 
• 61190-04-3 (2,2-Diethoxy-ethyl)-[1-(3-methoxy-phenyl)-meth-(Z)-ylidene]-amine 
• 6065-82-3 Ethyl diethoxyacetate 
• 1351592-58-9 (E)-2,2-diethoxy-N-(3-methoxybenzylidene)ethanamine 
• 645-36-3 2,2-diethoxy-ethanamine 
• 591-31-1 3-methoxy-benzaldehyde 
• 61189-99-9 diethoxyacetamide 
• 41365-75-7 aminopropane diethyl acetal 

Downstream Products

• 39989-39-4 7-methoxyisoquinoline 
• 1351592-62-5 (7-methoxyisoquinolin-4-yl)(3,4,5-trimethoxyphenyl)methanone nitrate 
• 1351592-61-4 (7-methoxyisoquinolin-4-yl)(3,4,5-trimethoxyphenyl)methanone 
• 1351593-25-3 (7-methoxyisoquinolin-4-yl)(3,4,5-trimethoxy-2-nitrophenyl)methanone 
• 1351592-59-0 4-(3,4,5-trimethoxybenzyl)-7-methoxyisoquinoline 

Relevant articles and documents

SUBSTITUTED ISOQUINOLINES AND THEIR USE AS TUBULIN POLYMERIZATION INHIBITORS

The present invention relates generally to substituted isoquinolines and their use as tubulin polymerization inhibitors. In particular, the invention relates to substituted isoquinolines which possess useful therapeutic activity, use of these compounds in methods of therapy and the manufacture of medicaments as well as compositions containing these compounds

A ONE-POT ISOQUINOLINE SYNTHESIS BY CYCLODEHYDROGENATION OF BENZYLAMINOACETALS WITH CHLOROSULFONIC ACID

A direct preparation of the fully aromatized isoquinolines (3a-l) by the cyclodehydrogenation of benzylamnoacetals (2a-l) with chlorosulfonic acid is described.Comparing the behavior of chlorosulfonic acid with that of sulfuric acid toward 1,2-dihydroisoquinoline, it is able to be suggested that benzylaminoacetals were cyclized first to 1,2-dihydroisoquinolines, subsequently, dehydrogenated to the fully aromatized isoquinolines by the hydride abstraction with ClSO3H.Subtitution by a larger R3 group than isopropyl in the acetal ArCH(R3)NHCH2CH(OEt)2, interfered this second step, so the corresponding isoquinolines could not be obtained.