61193-37-1Relevant articles and documents
Synthesis and antiviral activities of N-9-oxypurine 1,3-dioxolane and 1,3-oxathiolane nucleosides
Nguyen-Ba, Nghe,Lee, Nola,Chan, Laval,Zacharie, Boulos
, p. 2223 - 2226 (2007/10/03)
Two series of 1,3-dioxolanes and 1,3-oxathiolane nucleosides containing N-9-oxypurine were synthesized as potential antiviral agents. These compounds were prepared by reacting the sugar moieties with iodo- or bromotrimethylsilane, followed by treatment with a mixture of sodium hydride and the desired N-hydroxy purine base. The preparation of these N-hydroxybases was also described. No significant antiviral activity was observed against HIV, HBV, HSV-1, HSV-2, or HCMV. (C) 2000 Elsevier Science Ltd.
Antiviral phosphonylalkoxy purines
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, (2008/06/13)
A compound of formula (I), or a pharmaceutically acceptable salt thereof: STR1 wherein R1 is hydroxy or amino; R2 is hydrogen or amino; R3 is hydrogen, hydroxymethyl or acyloxymethyl; R4 is hydrogen or (when Rs
Purine N-oxides. 66. Synthesis of 9-hydroxyadenine.
Watson
, p. 1610 - 1612 (2007/10/09)
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