124077-21-0Relevant articles and documents
Synthesis and antiviral activities of N-9-oxypurine 1,3-dioxolane and 1,3-oxathiolane nucleosides
Nguyen-Ba, Nghe,Lee, Nola,Chan, Laval,Zacharie, Boulos
, p. 2223 - 2226 (2007/10/03)
Two series of 1,3-dioxolanes and 1,3-oxathiolane nucleosides containing N-9-oxypurine were synthesized as potential antiviral agents. These compounds were prepared by reacting the sugar moieties with iodo- or bromotrimethylsilane, followed by treatment with a mixture of sodium hydride and the desired N-hydroxy purine base. The preparation of these N-hydroxybases was also described. No significant antiviral activity was observed against HIV, HBV, HSV-1, HSV-2, or HCMV. (C) 2000 Elsevier Science Ltd.
SYNTHESIS OF 9-HYDROXYPURINES: INTERMEDIATES TO NOVEL ANTIVIRAL ACYCLONUCLEOSIDES
Harnden, M. R.,Wyatt, P. G.
, p. 2185 - 2188 (2007/10/02)
Synthetic approaches to 2--9-hydroxy-6-methoxypurine (7) and 9-hydroxy-6-phthalimidopurine (15) are described.These 9-hydroxypurines are useful intermediates in the synthesis of 9-alkoxyguanine and 9-alkoxyadenine derivatives