61195-17-3

Upstream product

• 120-57-0 piperonal 
• 134-20-3 2-carbomethoxyaniline 
• 33263-03-5 2-azidobenzoic amide 
• 610-15-1 2-nitrobenzamide 
• 118-48-9 isatoic anhydride 
• 28144-70-9 anthranilic acid amide 

Relevant academic research and scientific papers

PEG-SO3H as eco-friendly polymeric catalyst for the synthesis of 2,3-dihydroquinazolinones in water

A facile, efficient, green, and environmentally benign method is described for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones by direct cyclocondensation of 2-aminobenzamide with aldehydes or ketones in water using PEG-SO3H as an acidic catalyst under room temperature. This new method totally avoids the use of organic acids, toxic or expensive solvents and affording the corresponding product in good to excellent yields in this reaction.

Inclusion complex of Isatoic anhydride with β-cyclodextrin and supramolecular one-pot synthesis of 2, 3-dihydroquinazolin-4(1H)-ones in aqueous media

The inclusion complex of isatoic anhydride with β-cyclodextrin was formed as a result of intermolecular interaction between isatoic anhydride with β-CD. The inclusion complex was confirmed by IR spectroscopy, X-ray diffraction and DSC studies. From application of complex, herein we have described a simple and efficient protocol for synthesis of 2, 3-dihydroquinazoline-4(1H)-one derivatives by one pot condensation of isatoic anhydride, ammonium acetate or amine and aldehyde using β-CD as a supramolecular catalyst in aqueous media.

Efficient synthesis of 2,3-dihydroquinazolin-4(1H)-ones using heterogeneous solid acid catalysts: Unexpected formation of 2,3-dihydro-2-(4-(tetrahydro-2H- pyran-2-yloxy)butyl)quinazolin-4(1H)-one

The heterogeneous solid acid catalysts Amberlyst-15 and silica-HClO 4 displays efficient catalytic properties for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones from anthranilamide and various aldehydes/ketones under mild reaction conditions and in good yields. These catalysts also showed good catalytic activity for condensation of anthranilamide with a cyclic enol ether 3,4-dihydropyran and led to formation of new unexpected quinazolinone product 6 comprising two dihydropyran moieties. The new product 6 has been reported for the first time and is fully characterized using 2D-NMR data. Furthermore, both solid acid catalysts can be easily recycled without significant loss of activity. ARKAT-USA, Inc.

An efficient synthesis of quinazoline derivatives with the aid of low-valent titanium reagent

Quinazolin-4(3H)-ones, 1,2-dihydroquinazolin-4(3H)-ones, 3,4-dihydroquinazolines, imidazo[1,2-c]-quinazolines and 5,6-dihydroimidazo[1,2- c]quinazolines were synthesized by the novel reductive reaction of nitro group, N-H bond and ortho-ester, aldehydes o

A facile synthesis of 1,2-dihydroquinazolin-4(3H)-ones with the aid of a low-valent titanium reagent

A short and facile synthesis of a series of 1,2-dihydroquiazolin-4(3H) -ones was accomplished in good yields via the novel reductive cyclisation of o-nitrobenzamides with aldehydes or ketones promoted by the TiCl4/Sm system. Structures were established on the basis of elemental analysis, IR, 1H NMR and confirmed by a single-crystal X-ray diffraction analysis, The advantages of our method are easily accessible starting materials, convenient manipulation and moderate to high yields.

Synthesis of quinazolin-4(3H)-ones and 1,2-dihydroquinazolin-4(3H)-ones with the aid of a low-valent titanium reagent

A short and facile synthesis of a series of quinazolin-4(3H)-ones and 1,2-dihydroquinazolin-4(3H)-ones was accomplished in good yields via the novel reductive cyclization of o-nitrobenzamides and triethyl orthoformate, aldehydes or ketones promoted by TiCl4/Zn.

Facile synthesis of 2,3-dihydro-2-aryl-4(1H)-quinazolinones promoted by Sml2

2,3-Dihydro-2-aryl-4(1H)-quinazolinones were prepared in good yields via reductive cyclisation of o-azidobeneamides with aldehydes and ketones promoted by Sml2 under mild and neutral conditions.

A one-pot synthesis of 2-aryl-2,3-dihydro-4(1H)-quinazolinones by use of samarium iodide

2-Aryl-2,3-dihydro-4(1H)-quinazolines have been prepared in a one-pot synthesis by samarium idoide (SmI2) promoted reaction of o-nitrobenzamide and aldehydes.