61200-60-0

Basic information

• Product Name: 2,5-DICHLOROTHIOPHENE-3-CARBALDEHYDE, 97
• Synonyms: 2,5-Dichlorothiophene-3-carbaldehyde;2,5-DICHLOROTHIOPHENE-3-CARBALDEHYDE, 97;3-Thiophenecarboxaldehyde, 2,5-dichloro-;2,5-Dichloro-3-formylthiophene;2,5-dichloro-3-Thiophenecarboxaldehyde
• CAS NO: 61200-60-0
• Molecular Formula: C₅H₂Cl₂OS
• Molecular Weight: 181.03978
• Mol File: 61200-60-0.mol

Chemical Properties

• Melting Point: 24.0-24.5 °C
• Boiling Point: 229.8 °C at 760 mmHg
• Flash Point: 92.8 °C
• Appearance: /
• Density: 1.581 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 2,5-DICHLOROTHIOPHENE-3-CARBALDEHYDE, 97(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-DICHLOROTHIOPHENE-3-CARBALDEHYDE, 97(61200-60-0)
• EPA Substance Registry System: 2,5-DICHLOROTHIOPHENE-3-CARBALDEHYDE, 97(61200-60-0)

Safety Data

• Hazard Codes: Xn:Harmful
• Statements: R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.; R36/37/38:Irritating to eyes, respiratory system
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S36/37/39:Wear suitabl
• Hazardous Substances Data: 61200-60-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2,5-DICHLOROTHIOPHENE-3-CARBALDEHYDE, 97 is used as a key building block for the synthesis of various pharmaceuticals. Its unique chemical structure allows it to be a versatile component in the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 2,5-DICHLOROTHIOPHENE-3-CARBALDEHYDE, 97 serves as an essential component in the creation of agrochemicals. Its properties make it suitable for use in the formulation of pesticides and other agricultural chemicals that are designed to protect crops and enhance agricultural productivity.
Used in Organic Dyes Industry:
2,5-DICHLOROTHIOPHENE-3-CARBALDEHYDE, 97 is utilized as a precursor in the synthesis of organic dyes. Its chemical properties enable the production of a wide range of dyes with specific color characteristics, which are used in various applications such as textiles, plastics, and printing inks.
Used in Heterocyclic Compounds Synthesis:
2,5-DICHLOROTHIOPHENE-3-CARBALDEHYDE, 97 is used as a precursor in the synthesis of heterocyclic compounds. Its involvement in the formation of these complex ring structures is crucial for the development of new chemical entities with potential applications in various fields.
Used in Material Development:
2,5-DICHLOROTHIOPHENE-3-CARBALDEHYDE, 97 is also used in the development of new materials. Its unique properties allow it to contribute to the creation of innovative materials with specific characteristics, which can be applied in various industries.
Used in Research and Development:
In the chemical and pharmaceutical industries, 2,5-DICHLOROTHIOPHENE-3-CARBALDEHYDE, 97 is employed in research and development activities. Its role in these activities is vital for the discovery and development of new chemical processes and products.

Upstream product

• 3172-52-9 2,5-diclorothiophene 
• 4885-02-3 Dichloromethyl methyl ether 
• 68-12-2 N,N-dimethyl-formamide 
• 14345-98-3 2-chlorothiophene-3-carboxaldehyde 

Downstream Products

• 5425-39-8 2,5-dichloro-thiophene-3-carbaldehyde thiosemicarbazone 
• 36157-41-2 2,5-dichlorothiophene-3-carboxylic acid 

Relevant articles and documents

Continuous flow magnesiation of functionalized heterocycles and acrylates with TMPMgCl·LiCl

A flow procedure for the metalation of functionalized heterocycles (pyridines, pyrimidines, thiophenes, and thiazoles) and various acrylates using the strong, non-nucleophilic base TMPMgCl·LiCl is reported. The flow conditions allow the magnesiations to be performed under more convenient conditions than the comparable batch reactions, which often require cryogenic temperatures and long reaction times. Moreover, the flow reactions are directly scalable without further optimization. Metalation under flow conditions also allows magnesiations that did not produce the desired products under batch conditions, such as the magnesiation of sensitive acrylic derivatives. The magnesiated species are subsequently quenched with various electrophiles, thereby introducing a broad range of functionalities. Go with the flow: Flow conditions allow a practical metalation of functionalized heterocycles and various acrylates in the presence of the base TMPMgCl·LiCl (TMP=2,2,6,6-tetramethylpiperidyl). More convenient temperatures and very fast reaction times can usually be achieved by applying the flow conditions. Sensitive acrylic derivatives can be magnesiated under flow conditions. Furthermore, the flow reactions are readily scalable without further optimization.

Aminoguanidine hydrazone derivatives, process for producing the same and drugs thereof

The present invention is to provide a compound of the formula: wherein the ring A is an optionally substituted 5- to 6-membered aromatic heterocyclic ring, the ring B an optionally substituted 5- to 6-membered aromatic homocyclic ring or an optionally sub

PROTONATION AND ELECTROPHILIC TRICHLOROMETHYLATION OF 2,5- AND 2,4-DICHLOROTHIOPHENES

Trichloromethylation of 2,5-dichlorothiophene, 1, and 2,4-dichlorothiophene, 2, with CCl4 and AlCl3 has been studied.It could be shown that in the case of 1 the reaction was directed to position 3 with formation of 2,5-dichloro-3-(trichloromethyl)thiophene, 3, the process being complicated by the formation of the isomeric 3,5-dichloro-2-(trichloromethyl)thiophene, 4, and 4,5-dichloro-2-(trichloromethyl)thiophene, 5, as well as linked products, i.e. a mixture of bis(dichlorothienyl)dichloromethanes (6).Trichloromethylation of 3 smoothly leads to 4, along with a small amount of bis(3,5-dichloro-2-thienyl)dichloromethane.It has also been found that, as a result of protonation, under the effect of HCl and AlCl3, the 2,5-dichloro derivative 1 was converted into the 2,4-dichloro isomer 2, which, under the reaction conditions, exist in the form of ?-complex, i.e. the 2H-3,5-dichlorothiophenium ion, stable at room temperature.The mechanism of trichloromethylation of 1, including the ipso-attack by the CCl3+ cation and isomerization during protonation, is discussed.

New imidazole anti-fungal agents derived from benzothiophene. Part II

1-thienyl)methyl>-1H-imidazoles 22, 1-thien-3-yl)(thienyl)methyl>-1H-imidazoles 25 and 1-thien-3-yl)methyl>-1H-imidazoles 28 have been synthesized and tested for anti-fungal activity.All compounds showed good activity against a broad spectrum of fungi (yeasts, dermatophytes).