5722-93-0

Basic information

• Product Name: 2-HYDROXY-4,5-DIMETHOXY BENZOIC ACID
• Synonyms: 2-HYDROXY-4,5-DIMETHOXY BENZOIC ACID;4,5-DiMethoxysalicylic acid;2-Hydroxy-4,5-Dimethoxy Benzoic Acid (for Acotiamide);Acotiamide Impurity K;Acotiamide Hydrochloride impurity J
• CAS NO: 5722-93-0
• Molecular Formula: C₉H₁₀O₅
• Molecular Weight: 198.18
• EINECS: 1312995-182-4
• Mol File: 5722-93-0.mol
• Article Data: 10

Chemical Properties

• Melting Point: 213-214℃ (decomposition)
• Boiling Point: 361.5±42.0 °C(Predicted)
• Appearance: /
• Density: 1.335±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 3.13±0.10(Predicted)
• CAS DataBase Reference: 2-HYDROXY-4,5-DIMETHOXY BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDROXY-4,5-DIMETHOXY BENZOIC ACID(5722-93-0)
• EPA Substance Registry System: 2-HYDROXY-4,5-DIMETHOXY BENZOIC ACID(5722-93-0)

Safety Data

• Hazardous Substances Data: 5722-93-0(Hazardous Substances Data)

Usage

Uses

4,5-Dimethoxysalicylic Acid has been used as a reactant for the preparation of Salicylanilide derivatives as inhibitors of the protein tyrosine kinase epidermal growth factor receptor.

Upstream product

• 2033-89-8 3,4-dimethoxyphenol 
• 82658-22-8 (+/-)-Cervinomycin A₂ 
• 82658-23-9 Cervinomycin A₁ 
• 56-81-5 glycerol 
• 182014-79-5 2-acetoxy-4,5-dimethoxybenzaldehyde 
• 490-64-2 asaronic acid 
• 610-90-2 2,4,5-trihydroxybenzoic acid 
• 61203-48-3 2-iodo-4,5-dimethoxybenzoic acid 
• 6286-46-0 2-bromo-4,5-dimethoxybenzoic acid 
• 93-07-2 Veratric acid 
• 26759-46-6 methyl 2-amino-4,5-dimethoxybenzoate 
• 14382-91-3 2-hydroxy-4,5-dimethoxybenzaldehyde 
• 67-56-1 methanol 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 490-64-2 asaronic acid 
• 877997-98-3 2-hydroxy-4,5-dimethoxybenzoic acid phenyl ester 
• 877997-99-4 2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxylic acid methyl ester 
• 185104-11-4 2-[N-(4,5-dimethoxy-2-hydroxybenzoyl)amino]-4-[(2-diisopropyl-aminoethyl)aminocarbonyl]-1,3-thiazole hydrochloride 
• 185106-16-5 Acotiamide 
• 24258-45-5 2-Methoxycarbonyl-4.5-dimethoxy-phenoxyessigsaeure-ethylester 
• 911832-29-6 4,5-dimethoxy-2-(pyridin-4-ylmethoxy)-benzoic acid methyl ester 
• 28373-21-9 2-hydroxy-4,5-dimethoxybenzoic acid methyl ester 
• 854660-72-3 2-acetoxy-4,5-dimethoxy-benzoic acid 
• 2033-89-8 3,4-dimethoxyphenol 

Relevant articles and documents

Structure of cervinomycin, a novel antianaerobic antibiotic

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Acotiamide hydrochloride preparation method

The invention discloses an acotiamide hydrochloride preparation method. The acotiamide hydrochloride preparation method includes: taking 2,4,5-trihydroxybenzoic acid as a raw material easy to obtain, subjecting methyl iodide to selective methylation react

arab League tests for the amine and a method for the preparation of its hydrochloride (by machine translation)

The invention discloses a arab League tests for the amine method for preparing and its hydrochloride, 2 - [(2-hydroxy -4,5-dimethoxy-benzoyl) amino] - 1,3-thiazole-4-carboxylic acid methyl ester, and N, N-diisopropyl ethylenediamin in the molten state after reaction under N-[ 2 - (diisopropyl amino) ethyl] - 2 - [(2-hydroxy -4,5-dimethoxy-benzoyl) amino] - 1,3-thiazole-4-carboxamide, hydrochloric acid for hydrochloric acid prepared by adding dropwisely added methanol trihydrate arab League takes a test for somebody else the amine, the technical proposal of the present invention reduces the use of toluene, economic and convenient, the reaction is complete, process safety; reduced at the same time the residual toluene in the final product, and impurity 2 - [(2-hydroxy -4,5-dimethoxy-benzoyl) amino] - 4-carboxyl -1, the content of 3-thiazole, the product quality is promoted; and is easy to be refined and purification of the crude product, the reaction yield is high. (by machine translation)