5722-93-0

Usage

Uses

Used in Pharmaceutical Industry:
2-HYDROXY-4,5-DIMETHOXY BENZOIC ACID is used as a reactant for the preparation of Salicylanilide derivatives, which serve as inhibitors of the protein tyrosine kinase epidermal growth factor receptor. This application is significant in the development of targeted therapies for various diseases, including cancer.
Used in Chemical Synthesis:
2-HYDROXY-4,5-DIMETHOXY BENZOIC ACID can be utilized as a building block in the synthesis of various organic compounds, such as pharmaceuticals, agrochemicals, and other specialty chemicals. Its unique structure allows for further functionalization and modification to create a wide range of products with diverse applications.
Used in Research and Development:
Due to its unique chemical properties, 2-HYDROXY-4,5-DIMETHOXY BENZOIC ACID can be employed in research and development for the exploration of new chemical reactions, mechanisms, and potential applications in various fields, including material science, pharmaceuticals, and agrochemicals.

Upstream product

• 28373-21-9 2-hydroxy-4,5-dimethoxybenzoic acid methyl ester 
• 40357-54-8 6,7-dimethoxy-3-hydroxyflavone 
• 77184-81-7 3-hydroxy-4',6,7-trimethoxyflavone 
• 2033-89-8 3,4-dimethoxyphenol 
• 56-81-5 glycerol 
• 490-64-2 asaronic acid 
• 61203-48-3 2-iodo-4,5-dimethoxybenzoic acid 
• 854660-72-3 2-acetoxy-4,5-dimethoxy-benzoic acid 
• 610-90-2 2,4,5-trihydroxybenzoic acid 
• 6286-46-0 2-bromo-4,5-dimethoxybenzoic acid 
• 93-07-2 Veratric acid 
• 26759-46-6 methyl 2-amino-4,5-dimethoxybenzoate 
• 182014-79-5 2-acetoxy-4,5-dimethoxybenzaldehyde 
• 14382-91-3 2-hydroxy-4,5-dimethoxybenzaldehyde 

Downstream Products

• 2033-89-8 3,4-dimethoxyphenol 
• 854660-72-3 2-acetoxy-4,5-dimethoxy-benzoic acid 
• 490-64-2 asaronic acid 
• 28373-21-9 2-hydroxy-4,5-dimethoxybenzoic acid methyl ester 
• 877997-98-3 2-hydroxy-4,5-dimethoxybenzoic acid phenyl ester 
• 877997-99-4 2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxylic acid methyl ester 
• 185104-11-4 2-[N-(4,5-dimethoxy-2-hydroxybenzoyl)amino]-4-[(2-diisopropyl-aminoethyl)aminocarbonyl]-1,3-thiazole hydrochloride 
• 185106-16-5 Acotiamide 
• 911832-29-6 4,5-dimethoxy-2-(pyridin-4-ylmethoxy)-benzoic acid methyl ester 
• 24258-45-5 2-Methoxycarbonyl-4.5-dimethoxy-phenoxyessigsaeure-ethylester 

Relevant academic research and scientific papers

A xylochemically inspired synthesis of lamellarin G trimethyl ether via an enaminone intermediate

A concise high yielding synthesis of lamellarin G trimethyl ether has been achieved from precursors and solvents that can in principle be derived from xylochemical (woody biomass) sources. The route is comparatively green in that some reactions are performed without solvent or with relatively benign solvents. In addition, chromatographic purification of products is avoided, and only a single aqueous workup is performed. The novelty of the synthesis lies in the intermediacy of an enaminone for the construction of the central pyrrole ring. The overall yield of the product is among the highest reported to date.

Acotiamide hydrochloride preparation method

The invention discloses an acotiamide hydrochloride preparation method. The acotiamide hydrochloride preparation method includes: taking 2,4,5-trihydroxybenzoic acid as a raw material easy to obtain, subjecting methyl iodide to selective methylation react

Preparation of 2 - hydroxy - 4, 5 - dimethoxy benzoic acid method

The invention discloses a method for preparing a compound of formula (2). The method is characterized in that linear or annular amine reacts with a compound of formula (1) in a polar aprotic solvent to obtain the compound of formula (2). The method has th

arab League tests for the amine and a method for the preparation of its hydrochloride (by machine translation)

The invention discloses a arab League tests for the amine method for preparing and its hydrochloride, 2 - [(2-hydroxy -4,5-dimethoxy-benzoyl) amino] - 1,3-thiazole-4-carboxylic acid methyl ester, and N, N-diisopropyl ethylenediamin in the molten state after reaction under N-[ 2 - (diisopropyl amino) ethyl] - 2 - [(2-hydroxy -4,5-dimethoxy-benzoyl) amino] - 1,3-thiazole-4-carboxamide, hydrochloric acid for hydrochloric acid prepared by adding dropwisely added methanol trihydrate arab League takes a test for somebody else the amine, the technical proposal of the present invention reduces the use of toluene, economic and convenient, the reaction is complete, process safety; reduced at the same time the residual toluene in the final product, and impurity 2 - [(2-hydroxy -4,5-dimethoxy-benzoyl) amino] - 4-carboxyl -1, the content of 3-thiazole, the product quality is promoted; and is easy to be refined and purification of the crude product, the reaction yield is high. (by machine translation)

METHOD FOR PRODUCING 2-BROMO-4,5-DIALKOXY BENZOIC ACID

Provided is a method for effectively producing a 4,5-dialkoxy-2-hydroxybenzoic acid from an inexpensive raw material. A method for producing a 2-bromo-4,5-dialkoxybenzoic acid represented by the following formula (2): (wherein each of R1 and R2 represents a lower alkyl group), the method including causing a 3,4-dialkoxybenzoic acid represented by the following formula (1): (wherein R1 and R2 have the same meanings as defined above) to react with bromine in concentrated hydrochloric acid.

METHOD FOR PRODUCING AMINOTHIAZOLE DERIVATIVE AND PRODUCTION INTERMEDIATE

Provided is a method for selectively demethylating a 2-methoxy group. Specifically provided is a production method of a compound represented by formula (7) below through the following reactions.

METHOD FOR PRODUCING AMINOTHIAZOLE DERIVATIVE AND PRODUCTION INTERMEDIATE

Disclosed is a selective demethylation process of a 2-methoxy group. Specifically disclosed is a method for producing a compound represented by the formula (7) below through the following reactions.

Synthesis and biological evaluation of benzamides and benzamidines as selective inhibitors of VEGFR tyrosine kinases

A series of benzamidines and benzamides was synthesized as selective inhibitors of vascular endothelial growth factor receptor (VEGFR) tyrosine kinases, and tested for inhibitory activity toward autophosphorylation by the enzyme assay. Selective inhibitio

The Reaction of 3-Hydroxyflavones with Metal Salts

The reaction of 3-hydroxyflavones (1a-d) with lead(IV) acetate gave 1,2-diphenylethanediones (2a-d), 1,2-diphenyl-2-hydroxyethanones, 2-hydroxybenzoic acids (7 and 9), and benzoic acids (8 and 10), and the reaction with manganese(III) acetate yielded 2, 7, 8, 9, and 10.In addition to 2, 7, and 10, 6-methoxy-2-(4-methoxybenzoyloxy)-3(2H)-benzofuranone and 2-hydroxy-4-methoxybenzaldehyde were obtained in the reaction of 1c with manganese(III) acetate.It has been established by the studies of 14C-labelled compounds that the C(3) in the 3-hydroxyflavone was lost during the reaction.