6121-45-5

Basic information

• Product Name: 1-Methyl-2,3-diphenyl-1H-indole
• Synonyms: 1-Methyl-2,3-diphenyl-1H-indole
• CAS NO: 6121-45-5
• Molecular Formula: C₂₁H₁₇N
• Molecular Weight: 283.37
• Mol File: 6121-45-5.mol
• Article Data: 41

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Methyl-2,3-diphenyl-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methyl-2,3-diphenyl-1H-indole(6121-45-5)
• EPA Substance Registry System: 1-Methyl-2,3-diphenyl-1H-indole(6121-45-5)

Safety Data

• Hazardous Substances Data: 6121-45-5(Hazardous Substances Data)

Usage

Molecular weight

267.35 g/mol
The molecular weight of 1-Methyl-2,3-diphenyl-1H-indole is 267.35 grams per mole, which is a measure of its mass.

Physical state at room temperature

Dark colored solid
At room temperature, 1-Methyl-2,3-diphenyl-1H-indole exists as a dark colored solid, indicating its stability in this form.
6. Potential biological activities
1-Methyl-2,3-diphenyl-1H-indole is known for its potential biological activities, which may include interactions with biological systems or compounds.
7. Potential applications in medicine
Due to its potential biological activities, 1-Methyl-2,3-diphenyl-1H-indole is being studied for possible applications in the field of medicine, such as drug development or targeted therapies.
8. Significance in science and industry
1-Methyl-2,3-diphenyl-1H-indole is a significant compound with various potential uses in both scientific research and industrial applications, such as the development of new pharmaceuticals or materials.

Upstream product

• 2739-12-0 N-methylaniline hydrochloride 
• 119-53-9 2-hydroxy-2-phenylacetophenone 
• 100-61-8 N-methylaniline 
• 1484-50-0 desyl bromide 
• 3469-20-3 2,3-diphenyl-1H-indole 
• 77-78-1 dimethyl sulfate 
• 74-88-4 methyl iodide 
• 54879-99-1 N-(2-benzoyloxyphenyl)-N-methylbenzamide 
• 6652-29-5 2-phenoxy-1,2-diphenylethanone 
• 117785-88-3 deoxybenzoin-(methyl-phenyl-hydrazone) 
• 618-40-6 1-Methyl-1-phenylhydrazine 
• 501-65-5 diphenyl acetylene 
• 143-66-8 sodium tetraphenyl borate 
• 452962-71-9 3-iodo-1-methyl-2-phenyl-1H-indole 

Downstream Products

• 54879-99-1 N-(2-benzoyloxyphenyl)-N-methylbenzamide 
• 110417-98-6 C₄₂H₃₃N₂⁽¹⁺⁾*BF₄^(1-) 
• 110417-97-5 1,1'-Dimethyl-2,3,2',3'-tetraphenyl-3H,1'H-[3,6']biindolyl-1-ium; perchlorate 

Relevant articles and documents

One-Pot Tandem ortho-Naphthoquinone-Catalyzed Aerobic Nitrosation of N-Alkylanilines and Rh(III)-Catalyzed C-H Functionalization Sequence to Indole and Aniline Derivatives

The nitroso group served as a traceless directing group for the C-H functionalization of N-alkylanilines, ultimately removed after functioning either as an internal oxidant or under subsequent reducing conditions. The unique ability of o-NQ catalysts to aerobically oxidize the N-alkylanilines without using solvents and stoichiometric amounts of oxidants has rendered the new opportunity to develop the telescoped catalyst systems without a need for directly handling the hazardous N-nitroso compounds.

Au-promoted Pd-catalyzed arylative cyclization of N,N-dimethyl-o-alkynylaniline with aryl iodides: Access to 2,3-diaryl indoles and mechanistic insight

We have developed a Au-promoted Pd-catalyzed cyclization/cross-coupling of N,N-dimethyl-o-alkynylaniline with aryl iododes to synthesize 2,3-diarylindoles under mild and base-free conditions. A related vinyl-Au species has been isolated through Au-promoted cyclization of N,N-dimethyl-o-alkynylaniline and structurally characterized. Further study on its reactivity suggests the vinyl-Au species might be out of catalytic cycle, and PhPd(OTf)(PPh3)2 is probably the reaction intermediate.

Room-temperature Pd/Ag direct arylation enabled by a radical pathway

Direct arylation is an appealing method for preparing π-conjugated materials, avoiding the prefunctionalization required for traditional cross-coupling methods. A major effort in organic electronic materials development is improving the environmental and economic impact of production; direct arylation polymerization (DArP) is an effective method to achieve these goals. Room-temperature polymerization would further improve the cost and energy efficiencies required to prepare these materials. Reported herein is new mechanistic work studying the underlying mechanism of room temperature direct arylation between iodobenzene and indole. Results indicate that room-temperature, Pd/Ag-catalyzed direct arylation systems are radical-mediated. This is in contrast to the commonly proposed two-electron mechanisms for direct arylation and appears to extend to other substrates such as benzo[b]thiophene and pentafluorobenzene.