61294-96-0

Basic information

• Product Name: 2H-Isoindole-1-carboxylic acid, 3-phenyl-, ethyl ester
• CAS NO: 61294-96-0
• Molecular Formula: C17H15NO2
• Molecular Weight: 265.312
• Mol File: 61294-96-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2H-Isoindole-1-carboxylic acid, 3-phenyl-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Isoindole-1-carboxylic acid, 3-phenyl-, ethyl ester(61294-96-0)
• EPA Substance Registry System: 2H-Isoindole-1-carboxylic acid, 3-phenyl-, ethyl ester(61294-96-0)

Safety Data

• Hazardous Substances Data: 61294-96-0(Hazardous Substances Data)

Upstream product

• 118553-20-1 N-(diphenylmethylene)-α,β-dehydroalanine ethyl ester 
• 17507-56-1 ethyl 2-diazo-2-(diethoxyphosphoryl)acetate 
• 7699-76-5 N-chloro-1,1-diphenylmethanimine 
• 22360-47-0 1,4-dihydro-1-phenyl-3H-2-benzopyran-3-one 
• 23107-96-2 (2-benzoyl-phenyl)-acetic acid 
• 200353-88-4 ethyl 4,7-dihydro-4β,7β-ethano-2H-isoindole-1-carboxylate 

Relevant articles and documents

Rh(III)-Catalyzed Coupling of N-Chloroimines with α-Diazo-α-phosphonoacetates for the Synthesis of 2 H-Isoindoles

We report herein the first use of N-chloroimines as effective synthons for directed C-H functionalization. Rh(III)-catalyzed coupling of N-chloroimines with α-diazo-α-phosphonoacetates allows for efficient dechlorinative/dephosphonative access to 2H-isoindoles. Further deesterification under Ni(II) catalysis enables the complete elimination of reactivity-assisting groups and full exposure of reactivity of C3 and N2 ring atoms for attaching structurally distinct appendages.

Efficient synthesis of isoindoles using supercritical carbon dioxide

Bicyclopyrroles were efficiently converted to the corresponding isoindoles by a retro Diels-Alder reaction in supercritical carbon dioxide. By adding ethylene gas as an oxygen scavenger, the isoindole yield was further improved.