61305-30-4

Upstream product

• 61305-35-9 (R)-4-((tert-butyldimethylsilyl)oxy)cyclopent-2-enone 
• 39637-99-5 (S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride 
• 60410-16-4 (1R,4S)-4-hydroxy-2-cyclopentene-1-yl acetate 
• 56745-67-6 (4S)-4-tert-butyldimethylsilyloxycyclopent-2-en-1-one 
• 61305-35-9 4-[(tert-butyldimethylsilyl)oxy]cyclopent-2-enone 
• 114717-75-8 trans-4-t-butyldimethylsiloxy-1,2-epoxycyclopentane 
• 91661-16-4 syn-4-(tert-butyldimethylsilyloxy)cyclopentene oxide 
• 61740-30-5 (1R,4R)-4-((tert-butyldimethylsilyl)oxy)cyclopent-2-enol 
• 177895-59-9 (1S,4R)-4-((tert-butyldimethylsilyl)oxy)cyclopent-2-en-1-yl pivalate 
• 178034-11-2 (3R,5S)-(+)-3-acetoxy-5-(trimethylacetyloxy)cyclopent-1-ene 
• 178034-12-3 (1S,4R)-4-hydroxycyclopent-2-enyl 2,2,2-trimethylacetate 
• 104069-09-2 (1S,4R)-4-((tert-butyldimethylsilyl)oxy)cyclopent-2-enol 

Relevant academic research and scientific papers

An improved preparation of highly enantiomerically enriched (R)-(+)-4-tert-butyldimethylsiloxy-2-cyclopenten-1-one

A convenient procedure for the preparation of the title compound of ≥99% ee is presented as well as simple analytical methods for the determination of the optical purity of the product and intermediates in the sequence.

PREPARATION OF PROLINE DERIVED LITHIUM AMIDE BASES AND THEIR USE IN ENANTIOSELECTIVE DEPROTONATION OF MESO EPOXIDES

An alternative method of preparation for a range of proline derived chiral lithium amide bases is described. (S)-2-(Pyrrolidinomethyl) pyrrolidine, prepared by the new route, has been used to deprotonate cis and trans tbutyldimethylisiloxy-3,4-epoxycyclopentane enantioselectively, thus generating chiral cis and trans tbutyldimethylsiloxy-2-cyclopenten-4-ols.The products had higher enantiomeric purity than those produced when the base was prepared by a previously reported method.