735269-96-2

Upstream product

• 61330-09-4 dimethyl 4-cyano-4-(3,4-dimethoxyphenyl)heptanedioate 
• 93-17-4 3,4-dimethoxyphenylacetonitrile 
• 292638-85-8 acrylic acid methyl ester 

Downstream Products

• 735270-09-4 {2-[9-(3,4-dimethoxy-phenyl)-3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-9-yl]-ethyl}-methyl-carbamic acid benzyl ester 
• 735270-13-0 {2-[1-(3,4-dimethoxy-phenyl)-4-trimethylsilanyloxy-cyclohex-3-enyl]-ethyl}-methyl-carbamic acid benzyl ester 
• 735270-15-2 {2-[3-bromo-1-(3,4-dimethoxy-phenyl)-4-oxo-cyclohexyl]-ethyl}-methyl-carbamic acid benzyl ester 
• 735270-11-8 {2-[1-(3,4-dimethoxy-phenyl)-4-oxo-cyclohexyl]-ethyl}-methyl-carbamic acid benzyl ester 
• 735270-19-6 methanesulfonic acid 2-[9-(3,4-dimethoxy-phenyl)-3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-9-yl]-ethyl ester 
• 735270-17-4 {2-[1-(3,4-dimethoxy-phenyl)-4-oxo-cyclohex-2-enyl]-ethyl}-methyl-carbamic acid benzyl ester 
• 735270-07-2 {2-[9-(3,4-dimethoxy-phenyl)-3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-9-yl]-ethyl}-methyl-amine 
• 735270-05-0 2-[9-(3,4-dimethoxy-phenyl)-3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-9-yl]-ethanol 
• 735269-99-5 9-(3,4-dimethoxy-phenyl)-3,3-dimethyl-1,5-dioxa-spiro[5.5]undecane-9-carbonitrile 
• 735270-03-8 9-(3,4-dimethoxy-phenyl)-3,3-dimethyl-9-vinyl-1,5-dioxa-spiro[5.5]undecane 
• 735270-01-6 9-(3,4-dimethoxy-phenyl)-3,3-dimethyl-1,5-dioxa-spiro[5.5]undecane-9-carbaldehyde 
• 6023-73-0 mesembrine 
• 51533-65-4 4-(3,4-dimethoxyphenyl)-4-cyanocyclohexanone 

Relevant academic research and scientific papers

A simple and efficient synthesis of (±)-mesembrine

A simple and efficient synthesis of (±)-mesembrine 1 is described employing double Michael addition and as the key step in 18% overall yield.

An efficient and scalable one-pot double Michael addition-Dieckmann condensation for the synthesis of 4,4-disubstituted cyclohexane β-keto esters

(Chemical Equation Presented) A simple, scalable, and efficient one-pot methodology for the synthesis of 4,4-disubstituted cyclohexane β-keto esters from benzylic nitriles or esters and methyl acrylate promoted by potassium tert-butoxide is described. The process relies on a tandem double Michael addition-Dieckmann condensation reaction, which results in the formation of three discrete carbon-carbon bonds in a single pot, including a quaternary center. The method allows for the convenient and rapid synthesis of a variety of 4-aryl-4-cyano-2-carbomethoxycyclohexanone and 4-aryl-2,4- biscarbomethoxycyclohexanone building blocks for use in natural products synthesis and medicinal chemistry.