6135-14-4

Usage

Uses

Used in Pharmaceutical Industry:
1-(Dimethylamino)-4,4-dimethylpent-1-en-3-one is used as a reagent in the synthesis of pharmaceuticals for its ability to facilitate the creation of complex organic molecules, contributing to the development of new medications and therapies.
Used in Fine Chemicals Industry:
In the production of fine chemicals, 1-(Dimethylamino)-4,4-dimethylpent-1-en-3-one is employed as a reagent, leveraging its properties to produce high-quality specialty chemicals for various applications, including fragrances, dyes, and other specialty products.
Used in Organic Synthesis:
As a key intermediate in organic synthesis, 1-(Dimethylamino)-4,4-dimethylpent-1-en-3-one is used to produce a range of other compounds, enabling the creation of diverse chemical products across various industries.
Safety and Handling:
Due to its highly flammable nature, 1-(Dimethylamino)-4,4-dimethylpent-1-en-3-one requires adherence to proper safety protocols and the use of appropriate protective equipment during its handling and storage. It should be kept away from heat and open flames to prevent accidents.

InChI:InChI=1/C9H15N3O3S/c1-2-11-5-10-8-12(6-11)7(15)9(3-13,4-14)16-8/h13-14H,2-6H2,1H3

Upstream product

• 22700-73-8 1-(dimethylamino)-4,4-dimethylpentan-3-one 
• 124-40-3 dimethyl amine 
• 68-12-2 N,N-dimethyl-formamide 
• 5469-26-1 1-Bromopinacolon 
• 75-97-8 3,3-dimethyl-butan-2-one 
• 1186-70-5 bis(dimethylamino)methoxymethane 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 75-44-5 phosgene 
• 52162-28-4 2,2-Diethoxy-3,3-dimethylbutane 
• 107-06-2 1,2-dichloro-ethane 
• 506-59-2 N,N-dimethylammonium chloride 
• 145930-89-8 (3,3-Dimethyl-2-oxo-butylsulfanylmethylene)-dimethyl-ammonium; bromide 
• 53400-42-3 N,N-dimethyl-N-(4,4-dimethyl-3-oxopentyl)ammonium chloride 
• 52421-65-5 N,N-dimethyl-N'-thiobenzoylformamidine 

Downstream Products

• 17321-94-7 2-amino-4-(trifluoromethyl)pyrimidine 

Relevant academic research and scientific papers

An expedient synthesis of highly functionalized 1,3-dienes by employing cyclopropenes asC4units

An efficient method has been described to synthesize dicarbonyl functionalized 1,3-dienes by cleaving the CC bond of enaminones with cyclopropenes in the presence of a rhodium catalyst. The acetate-substituted cyclopropenes are judiciously chosen as standardC4units of 1,3-diene precursors. The reactions are believed to undergo a unique cutting and insertion process, involving a CC bond cleavage of the enaminone and insertion of a newC(sp2) source with the formation of two C-C single bonds. A broad range of substrates can be used to synthesize the corresponding 1,3-dienes under very mild reaction conditions, including low catalyst-loading, ambient temperature, and a neutral reaction solvent.

One-Pot Synthesis of Symmetrical and Asymmetrical 3-Amino Diynes via Cu(I)-Catalyzed Reaction of Enaminones with Terminal Alkynes

An economical and efficient protocol for the direct construction of amino skipped diynes through the Cu(I)-catalyzed reaction of enaminones and terminal alkynes has been described. Different kinds of symmetrical and asymmetrical 3-amino diynes could be ob

Selective α-Methylation of Ketones

The convenient and scalable preparative approach for the two-step α-methylation of ketones is described. The optimized protocols for regioselective preparation of enaminones with further diastereoselective and functional groups tolerant hydrogenation to α-methylketones are developed. The scope and limitations of the proposed methodology are discussed. The advantages compared to known procedures are demonstrated. The unexpected role of acetone in the hydrogenation is suggested. The evaluation of the method for both early building block synthesis and late-stage CH-functionalization is shown. The elaborate procedures' preparability and scalability are demonstrated by the synthesis of several α-methyl ketones up to 100 g amount.

Design and evaluation of pyrazolopyrimidines as KCNQ channel modulators

Effective treatments of neuropathic pain have been a focus of many discovery programs. KCNQ (kv7) are voltage gated potassium channel openers that have the potential for the treatment of CNS disorders including neuropathic pain. Clinical studies have sugg

Directed C-C bond cleavage of a cyclopropane intermediate generated from: N -tosylhydrazones and stable enaminones: Expedient synthesis of functionalized 1,4-ketoaldehydes

An efficient method to construct functionalized 1,4-ketoaldehydes bearing all-carbon α-quaternary centers via regioselective C-C bond activation has been described. The cyclopropanation of bench-stable enaminones with in situ generated diazo reagents from

Heterocyclic Compounds Useful as RAF Kinase Inhibitors

The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.

COMPOUNDS USEFUL AS RAF KINASE INHIBITORS

The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.

PYRIDO PYRIMIDINONES, DIHYDRO PYRIMIDO PYRIMIDINONES AND PTERIDINONES USEFUL AS RAF KINASE INHIBITORS

The present invention provides compounds having the formula: (I) wherein A-B together represents one of the following structures; (II), (III), (IV) and n, R1, R2, R3, R4, L1, L2, Y and Z are as defined in classes and subclasses herein, and pharmaceutical compositions thereof, as described generally and in subclasses herein, which compounds are useful as inhibitors of protein kinase (e.g., RAF), and thus are useful, for example, for the treatment of RAF mediated diseases.

One-pot synthesis of some 2H-pyran-2-one derivatives

A one-pot synthesis of various 2H-pyran-2-one derivatives 5-19 starting from methyl ketones 1, N,N-dimethylformamide dimethyl acetal and N-acylglycines 3 in acetic anhydride is described.

STUDY OF THE ESCHENMOSER SULFIDE CONTRACTION METHOD WITH AND WITHOUT A THIOPHILE

Results obtained and observations made by applying the title method for the synthesis of enaminones 5a-o, using triphenylphosphine as a thiophile and triethylamine as a base, are reported.The product distributions of the deprotonations of α-phenacylthio iminium bromides with and without thiophile and those known from thiouronium and heterocyclic thionium analogs are compared.Key words: Enaminones; α-phenacylthio iminium bromides; disulfides; thiiranes.