61367-10-0

Basic information

• Product Name: 1-(2-chloroethyl)-3-[4-(hydroxymethyl)cyclohexyl]urea
• CAS NO: 61367-10-0
• Molecular Formula: C₁₀H₁₉ClN₂O₂
• Molecular Weight: 234.7231
• Mol File: 61367-10-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 446.4°C at 760 mmHg
• Flash Point: 223.8°C
• Density: 1.18g/cm³
• Vapor Pressure: 7.59E-10mmHg at 25°C
• Refractive Index: 1.517
• CAS DataBase Reference: 1-(2-chloroethyl)-3-[4-(hydroxymethyl)cyclohexyl]urea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-chloroethyl)-3-[4-(hydroxymethyl)cyclohexyl]urea(61367-10-0)
• EPA Substance Registry System: 1-(2-chloroethyl)-3-[4-(hydroxymethyl)cyclohexyl]urea(61367-10-0)

Safety Data

• Hazardous Substances Data: 61367-10-0(Hazardous Substances Data)

Usage

General Description

1-(2-chloroethyl)-3-[4-(hydroxymethyl)cyclohexyl]urea is a chemical compound with potential therapeutic and pharmaceutical applications. It is a urea derivative featuring a chloroethyl and hydroxymethyl substituent on the cyclohexyl ring. 1-(2-chloroethyl)-3-[4-(hydroxymethyl)cyclohexyl]urea may exhibit antitumor and cytotoxic properties, making it a potential candidate for cancer treatment. Additionally, it may also have applications in drug development and medicinal chemistry due to its structural features and potential biological activities. However, further research and evaluation are necessary to fully understand the pharmacological potential and any potential side effects of this compound.

Upstream product

• 2084-28-8 trans-4-aminocyclohexanecarboxylic acid ethyl ester hydrochloride 
• 1943-83-5 2-chloroethyl isothiocyanate 
• 1467-84-1 ((1R,4R)-4-aminocyclohexyl)methanol 

Downstream Products

• 61367-15-5 1-(2-Chloro-ethyl)-3-(4-chloromethyl-cyclohexyl)-urea 
• 61367-11-1 C₁₁H₁₈ClN₃O₄ 

Relevant articles and documents

Synthesis of analogues of N (2 chloroethyl) N' trans 4 methylcyclohexyl) N nitrosourea for evaluation as anticancer agents

The superior activity of N (2 chloroethyl) N' (trans 4 methylcyclohexyl) N nitrosourea (MeCCNU) against advanced murine Lewis lung carcinoma in comparisons with the cis form and other nitrosoureas prompted the synthesis of a number of MeCCNU analogues, including several cis trans pairs. The methyl group was replaced by a variety of substituents (CO2H, CH2CO2H, CO2Me, CH2OAc, CH2Cl, OMe); the trans 3 methylcyclohexyl, cis 2 methyl 1,3 dithian 5 yl, cis and trans 2 methyl 1,3 dithian 5 yl tetraoxide, and 1 methylhexyl (open chain) analogues were also prepared. Preliminary tests against murine leukemia L1210 revealed therapeutic indices (ED50/LD10) ranging from 0.26 to 0.79; all but 3 analogues effected 50% cure rates at nontoxic doses, the open chain analogue being one of the least active. In terms of therapeutic index, diequatorial (trans 4) isomers were, with one exception, as active as or, in 4 of the 8 examples, somewhat more active than the corresponding axial equatorial (cis 4) isomers. In this series, 4 of the 5 2-fluoroethyl analogues prepared were clearly inferior to the corresponding 2 chloroethyl analogues.