61367-15-5

Usage

Uses

Used in Pharmaceutical Industry:
1-(2-chloroethyl)-3-[4-(chloromethyl)cyclohexyl]urea is used as a potential anti-cancer agent for its cytotoxic and antitumor properties. It is being studied for its ability to target and eliminate cancer cells, making it a promising candidate for cancer treatment.
Used in Cancer Research:
In the field of cancer research, 1-(2-chloroethyl)-3-[4-(chloromethyl)cyclohexyl]urea serves as a subject of investigation to understand its mechanism of action and potential synergistic effects with other chemotherapeutic drugs. This research aims to enhance its therapeutic outcomes and develop novel drug delivery systems to improve its bioavailability and efficacy against cancer cells.

Upstream product

• 61367-10-0 1-(2-Chloro-ethyl)-3-(4-hydroxymethyl-cyclohexyl)-urea 
• 1467-84-1 ((1R,4R)-4-aminocyclohexyl)methanol 
• 2084-28-8 trans-4-aminocyclohexanecarboxylic acid ethyl ester hydrochloride 

Relevant academic research and scientific papers

Synthesis of analogues of N (2 chloroethyl) N' trans 4 methylcyclohexyl) N nitrosourea for evaluation as anticancer agents

The superior activity of N (2 chloroethyl) N' (trans 4 methylcyclohexyl) N nitrosourea (MeCCNU) against advanced murine Lewis lung carcinoma in comparisons with the cis form and other nitrosoureas prompted the synthesis of a number of MeCCNU analogues, including several cis trans pairs. The methyl group was replaced by a variety of substituents (CO2H, CH2CO2H, CO2Me, CH2OAc, CH2Cl, OMe); the trans 3 methylcyclohexyl, cis 2 methyl 1,3 dithian 5 yl, cis and trans 2 methyl 1,3 dithian 5 yl tetraoxide, and 1 methylhexyl (open chain) analogues were also prepared. Preliminary tests against murine leukemia L1210 revealed therapeutic indices (ED50/LD10) ranging from 0.26 to 0.79; all but 3 analogues effected 50% cure rates at nontoxic doses, the open chain analogue being one of the least active. In terms of therapeutic index, diequatorial (trans 4) isomers were, with one exception, as active as or, in 4 of the 8 examples, somewhat more active than the corresponding axial equatorial (cis 4) isomers. In this series, 4 of the 5 2-fluoroethyl analogues prepared were clearly inferior to the corresponding 2 chloroethyl analogues.