613679-41-7Relevant academic research and scientific papers
Discovery of 4-amino and 4-hydroxy-1-aroylindoles as potent tubulin polymerization inhibitors
Liou, Jing-Ping,Wu, Zi-Yi,Kuo, Ching-Chuan,Chang, Chi-Yen,Lu, Pei-Yi,Chen, Chi-Ming,Hsieh, Hsing-Pang,Chang, Jang-Yang
supporting information; experimental part, p. 4351 - 4355 (2009/05/26)
1-Aroylindoline, 1-aroyl-1,2,3,4-tetrahydroquinoline, and 1-aroylindole derivatives were synthesized and evaluated for anticancer activity. The 4-amino and 4-hydroxy-1-aroylindoles 26 and 27 with IC50 of 0.9 and 0.6 μM, respectively, exhibited
Indole compounds
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, (2008/06/13)
This invention relates to methods of inhibiting tubulin polymerization and treating cancer and other angiogenesis-related disorders with indole compounds of the formula: wherein L1, L2, R1, R2, Ra, R
Indole compounds
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, (2008/06/13)
Indole compounds of the formula: wherein L1, L2, R1, R2, Ra, Rb, Rc, Rd, and Re are defined herein. Also disclosed are methods of using of the indole compou
Indole compounds as inhibitors of tubulin polymerisation for the treatment of angiogenesis-related disorders
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Page/Page column 25, (2010/02/10)
Indole compounds of the formula: wherein L1 is CO; L2 is a bond; R1 is aryl or heteroaryl; R2 is H, aryl, heteroaryl, halogen, nitro, nitroso, cyano, azide, isothionitro, OR, OC(O)R, OC(O)OR, OC(O)NRR', SO2
Indole compounds
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, (2008/06/13)
Indole compounds of the formula: 1wherein L1 is CO; L2 is a bond; R1 is aryl or heteroaryl; R2 is H, aryl, heteroaryl, halogen, nitro, nitroso, cyano, azide, isothionitro, OR, OC(O)R, OC(O)OR, OC(O)NRR′, SO
