1719-88-6

Basic information

• Product Name: 3,4,5-TRIMETHOXYBENZOIC ANHYDRIDE
• Synonyms: 3,4,5-TRIMETHOXYBENZOIC ANHYDRIDE;3,4,5-TRIMETHOXYBENZOIC ACID ANHYDRIDE;3,3',4,4',5,5'-hexamethoxybenzoic anhydride;3,4,5-TRIMETHOXYBENZOIC ACID ANHYDRIDE 97%;3,4,5-TRIMETHOXYBENZOIC ANHYDRIDE 95+%;Bis(3,4,5-trimethoxybenzoic)anhydride;NSC 40557
• CAS NO: 1719-88-6
• Molecular Formula: C₂₀H₂₂O₉
• Molecular Weight: 406.38
• EINECS: 217-010-8
• Mol File: 1719-88-6.mol
• Article Data: 11

Chemical Properties

• Melting Point: 155°C
• Boiling Point: 573.5°Cat760mmHg
• Flash Point: 249.9°C
• Appearance: /
• Density: 1.228g/cm³
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 3,4,5-TRIMETHOXYBENZOIC ANHYDRIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4,5-TRIMETHOXYBENZOIC ANHYDRIDE(1719-88-6)
• EPA Substance Registry System: 3,4,5-TRIMETHOXYBENZOIC ANHYDRIDE(1719-88-6)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 1719-88-6(Hazardous Substances Data)

Usage

General Description

3,4,5-Trimethoxybenzoic anhydride is a chemical compound with the molecular formula C12H10O5. It is a white crystalline solid that is commonly used in organic synthesis as a reagent for the formation of esters and amides. It is also utilized as a building block in the production of pharmaceuticals and agrochemicals. 3,4,5-TRIMETHOXYBENZOIC ANHYDRIDE is known for its strong acylation capabilities, making it an important intermediate in the synthesis of various organic compounds. Additionally, 3,4,5-Trimethoxybenzoic anhydride is used as a reagent for the modification of natural products and as a building block in the development of new materials and functional molecules. However, it is important to handle this compound with caution, as it is a potential irritant and can cause skin and eye irritation upon contact.

Upstream product

• 3840-31-1 (3,4,5-trimethoxyphenyl)methanol 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 56-23-5 tetrachloromethane 
• 4521-61-3 3,4,5-Trimethoxybenzoyl chloride 
• 107-21-1 ethylene glycol 
• 538-75-0 dicyclohexyl-carbodiimide 
• 118-41-2 Eudesmic acid 

Downstream Products

• 53165-02-9 5-hydroxy-3',4',5'-trimethoxyflavone 
• 858801-52-2 6-hydroxy-3,7-dimethoxy-2-(3,4,5-trimethoxy-phenyl)-chromen-4-one 
• 67197-57-3 5,6-dihydroxy-7-methoxy-2-(3,4,5-trimethoxy-phenyl)-chromen-4-one 
• 124909-81-5 6-hydroxy-3,5,7-trimethoxy-2-(3,4,5-trimethoxy-phenyl)-chromen-4-one 
• 122741-34-8 ent-11,17β-dimethoxy-3-oxo-18α-(3,4,5-trimethoxy-benzoyloxy)-2,3-seco-15β-yohimban-16α-carboxylic acid methyl ester 
• 137502-80-8 6-hydroxy-2-(3,4,5-trimethoxy-phenyl)-chromen-4-one 
• 4655-41-8 3,4,5-trimethoxy-benzoic acid-[5]isoquinolyl ester 
• 124909-84-8 5,6-Dihydroxy-3,7-dimethoxy-2-(3,4,5-trimethoxy-phenyl)-chromen-4-one 
• 95165-17-6 5-hydroxy-3,6,7,8,3',4',5'-heptamethoxyflavone 
• 49834-25-5 3,4,5-trimethoxy(N-tert-butylcarbamoyl)benzene 
• 175712-75-1 1-phenyl-2-(3,4,5-trimethoxyphenyl)-1H-benzo[d]imidazole 
• 1041752-06-0 5-methoxycarbonyl-1-(3',4',5'-trimethoxybenzoyl)indole 
• 870483-62-8 5-methyl-1-(3',4',5'-trimethoxybenzoyl)indole 
• 1041752-08-2 2-ethoxycarbonyl-5-methoxy-1-(3',4',5'-trimethoxybenzoyl)indole 

Relevant articles and documents

TBHP-promoted and iodide-catalyzed synthesis of anhydrides via cross dehydrogenative coupling (CDC) of aldehydes

We have successfully developed a transition metal free green methodology for the synthesis of carboxylic anhydrides from aldehydes via CDC pathway and have also demonstrated the reaction mechanism. The developed method has also been successfully applied for the synthesis of amides.

Efficient synthesis of symmetrical anhydrides by cross dehydrogenative coupling of aryl aldehydes over CuFe2O4 nanoparticles

Nano copper ferrite catalyst is prepared and characterized by scanning electron microscopy, energy dispersive X-ray, X-ray diffraction, vibrational sample magnetometry, and Fourier transform infrared. The catalytic activity is probed for cross-dehydrogenative coupling of aromatic aldehydes in the presence of tert-butyl hydroperoxide as the oxidant. This catalytic protocol appears as a simple, rather cheap, clean, and efficient practical strategy for the synthesis of symmetrical anhydrides, with proper efficiency (66%). The catalyst can be easily separated from the reaction mixture by an external magnet and reused several times in subsequent reactions, without any measurable loss of its efficiency. Graphic abstract: [Figure not available: see fulltext.]

Oxidative self-coupling of aldehydes in the presence of CuCl2/TBHP system: Direct access to symmetrical anhydrides

A simple synthesis of symmetrical anhydrides has been developed. Using tert-butylhydroperoxide (TBHP) as the oxidant and copper(II) chloride as the catalyst in acetonitrile, various aromatic and heteroaromatic aldehydes were reacted to provide symmetrical anhydrides in modest to good yields.