61370-88-5 Usage
Description
(DES-TYR1)-MET-ENKEPHALIN is a pentapeptide and an opioid peptide that has been investigated for its biological activity. It is a derivative of enkephalin, a naturally occurring neurotransmitter found in the brain and known for its involvement in regulating pain perception. The term "(DES-TYR1)-MET-ENKEPHALIN" indicates that the tyrosine (Tyr1) residue from the native met-enkephalin sequence has been removed. This modification does not significantly affect the chemical's binding affinity to opiate receptors but influences its metabolic stability and duration of biological activity. The primary biological action of (DES-TYR1)-MET-ENKEPHALIN is related to its binding and activation of opioid receptors, contributing to pain regulation and other physiological processes.
Uses
Used in Pharmaceutical Industry:
(DES-TYR1)-MET-ENKEPHALIN is used as an analgesic agent for its ability to bind and activate opioid receptors, which helps in regulating pain perception. This makes it a potential candidate for the development of pain management therapies.
Used in Research Applications:
(DES-TYR1)-MET-ENKEPHALIN is used as a research tool for studying the mechanisms of opioid receptor binding and activation, as well as the role of these receptors in pain regulation and other physiological processes. This can aid in the development of new therapeutic strategies for pain management and other conditions related to the opioid system.
Used in Drug Development:
(DES-TYR1)-MET-ENKEPHALIN is used as a lead compound in the development of new drugs targeting the opioid receptors. Its metabolic stability and duration of biological activity make it a valuable starting point for designing more effective and longer-lasting pain management medications.
Check Digit Verification of cas no
The CAS Registry Mumber 61370-88-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,1,3,7 and 0 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 61370-88:
(7*6)+(6*1)+(5*3)+(4*7)+(3*0)+(2*8)+(1*8)=115
115 % 10 = 5
So 61370-88-5 is a valid CAS Registry Number.
InChI:InChI=1/C18H26N4O5S/c1-28-8-7-13(18(26)27)22-17(25)14(9-12-5-3-2-4-6-12)21-16(24)11-20-15(23)10-19/h2-6,13-14H,7-11,19H2,1H3,(H,20,23)(H,21,24)(H,22,25)(H,26,27)/t13-,14-/m0/s1
61370-88-5Relevant articles and documents
Phosphorylation of enkephalins enhances their proteolytic stability
Dass, Chhabil,Mahalakshmi
, p. 1039 - 1045 (2007/10/03)
Pharmacological action of enkephalins as opioid peptides is limited because of their rapid degradation by endoproteases. A novel approach is used in this study to prolong the life of those peptides. Phosphorylation of N-terminal tyrosine residue is found to have a profound influence in improving the stability of [Met]enkephalin and [Leu]enkephalin against the action of aminopeptidase M. Whereas, breakdown of [Met]enkephalin and [Leu]enkephalin is essentially complete in less than one min when incubated at 37°C with purified aminopeptidase M (EC 3.4.11.2; substrate:enzyme = 1:0.1) in Tris buffer (pH 7.02), the corresponding phospho analogs are still detected 60 min after start of incubation. The rate of disappearance of phospho-[Met]enkephalin and phospho-[Leu]enkephalin follows first-order kinetics with half-lives of 7.3 and 8.8 min, respectively.
Synthesis of fragments of human β-lipotropin, β(h)-LPH. Part VI. The synthesis of des-1-tyrosine-α-endorphin and shortened peptides
Bijl,Van Nispen,Greven
, p. 469 - 474 (2007/10/02)
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