61372-56-3

Upstream product

• 124-41-4 sodium methylate 
• 588-63-6 3-phenoxypropyl bromide 
• 81842-71-9 toluene-4-sulfonic acid 3-hydroxy-propyl ester 
• 139-02-6 sodium phenoxide 
• 74-88-4 methyl iodide 
• 75322-09-7 3-cyclohexyloxypropyl alcohol 
• 108-94-1 cyclohexanone 
• 108-95-2 phenol 

Downstream Products

• 157840-15-8 (3-Vinyloxy-propoxy)-benzene 
• 264624-19-3 4-(3-methoxypropoxy)benzene-1-sulfonyl chloride 

Relevant academic research and scientific papers

NOVEL SEMI-SYNTHETIC GLYCOPEPTIDES AS ANTIBACTERIAL AGENTS

Semi-synthetic glycopeptides having antibacterial activity are described, in particular, the semi-synthetic glycopeptides described herein are made by chemical modification of the a glycopeptide (Compound A, Compound B, Compound H or Compound C) or the monosaccharide made by hydrolyzing the disaccharide moiety of the amino acid-4 of the parent glycopeptide in acidic medium to give the amino acid-4 monosaccharide; conversion of the monosaccharide to the amino-sugar derivative; acylation of the amino substituent on the amino acid-4 amino-substituted sugar moiety on these scaffolds with certain acyl groups; conversion of the amide group in amino acid-3 on these scaffolds to various acylamide, acylsulfonamide, acylsulfonylurea derivatives; aminomethylation with substituent containing sulfonamide or acylsulfonamide group on amino acid-7 through Mannich reaction; and conversion of the acid moiety on the macrocyclic ring of these scaffolds to certain substituted amides. Also provided are methods for the synthesis of the compounds, pharmaceutical compositions containing the compounds, and methods of use of the compounds for the treatment and/or prophylaxis of diseases, especially bacterial infections.

Keratinocyte growth inhibitors and hydroxamic acid derivatives

This invention relates to a keratinocyte-proliferation inhibitor comprising as active ingredient a compound having an activity of inhibiting the solubilization of heparin-binding EGF-like growth factor bound to cell membranes and a compound of the formula (I); or pharmaceutically acceptable salt thereof, wherein R1, R2, R3 are hydrogen atom or alkyl and X is substituted benzene or the like.

Regio- and Diastereo-Chemically Controlled Photocycloaddition of an Arene and an Alkene Linked by a Chiral Auxiliary

Intramolecular meta-arene alkene photocycloaddition of 1b, the substrate having a chiral auxiliary as a linking bridge between the arene and the alkene, resulted in high diastereofacial differentiation of the alkene at the addition step and sufficient regiocontrol of the subsequent ring closure step to give a single diastereomer 4.