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1-(3-nitrophenyl)pyrrolidin-2-one is a heterocyclic chemical compound with a molecular formula C11H10N2O3. It belongs to the pyrrolidin-2-one class of chemicals and features a nitrophenyl group. 1-(3-nitrophenyl)pyrrolidin-2-one has been studied for its potential medicinal properties, particularly as an anti-inflammatory and analgesic agent. Its unique chemical structure and properties also make it a candidate for use in pharmaceuticals and agrochemicals, highlighting its versatility in various fields of chemistry and medicine.

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  • 61372-79-0 Structure
  • Basic information

    1. Product Name: 1-(3-nitrophenyl)pyrrolidin-2-one
    2. Synonyms: 1-(3-nitrophenyl)pyrrolidin-2-one
    3. CAS NO:61372-79-0
    4. Molecular Formula: C10H10N2O3
    5. Molecular Weight: 206.198
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 61372-79-0.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: N/A
    9. CAS DataBase Reference: 1-(3-nitrophenyl)pyrrolidin-2-one(CAS DataBase Reference)
    10. NIST Chemistry Reference: 1-(3-nitrophenyl)pyrrolidin-2-one(61372-79-0)
    11. EPA Substance Registry System: 1-(3-nitrophenyl)pyrrolidin-2-one(61372-79-0)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 61372-79-0(Hazardous Substances Data)

61372-79-0 Usage

Uses

Used in Pharmaceutical Industry:
1-(3-nitrophenyl)pyrrolidin-2-one is used as a medicinal compound for its potential anti-inflammatory and analgesic properties, offering a promising therapeutic option for the treatment of pain and inflammation.
Used in Agrochemical Industry:
1-(3-nitrophenyl)pyrrolidin-2-one is utilized as a chemical constituent in agrochemicals, leveraging its unique structure and properties to contribute to the development of effective products for agricultural applications.

Check Digit Verification of cas no

The CAS Registry Mumber 61372-79-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,1,3,7 and 2 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 61372-79:
(7*6)+(6*1)+(5*3)+(4*7)+(3*2)+(2*7)+(1*9)=120
120 % 10 = 0
So 61372-79-0 is a valid CAS Registry Number.

61372-79-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(3-Nitrophenyl)pyrrolidin-2-one

1.2 Other means of identification

Product number -
Other names 1-(3-nitrophenyl)pyrrolidin-2-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:61372-79-0 SDS

61372-79-0Relevant articles and documents

Synthetic method of N - aryl substituted lactam compound

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Paragraph 0056-0058, (2021/08/25)

The invention discloses a method. NSynthesis method of - aryl substituted lactam compound, and synthesis method thereof is promoted by tertiary butyl hydroperoxide and-tert-butyl hydroperoxideNMulti-step series reaction synthesis - aryl substituted saturated cyclic amine compoundN- Aryl substituted lactam compounds are simple and convenient to operate. The method has the advantages of no transition metal catalysis, wide substrate application range and the like, and is suitable for industrial production.

Novel tertiary sulfonamides as potent anti-cancer agents

Okolotowicz, Karl J.,Dwyer, Mary,Ryan, Daniel,Cheng, Jiongjia,Cashman, Emily A.,Moore, Stephanie,Mercola, Mark,Cashman, John R.

supporting information, p. 4441 - 4451 (2018/08/03)

For adult women in the United States, breast cancer is the most prevalent form of cancer. Compounds that target dysregulated signal transduction can be efficacious anti-cancer therapies. A prominent signaling pathway frequently dysregulated in breast canc

Aluminium Chloride-Mediated Synthesis of 1-Chloro-2,2,2-Trifluoroethylidene-Substituted Pyrrolidones

Wang, Zeng,Yuan, Zihang,Han, Xiaoyan,Weng, Zhiqiang

supporting information, p. 2178 - 2182 (2018/04/25)

An aluminium chloride-mediated cascade reaction between pyrrolidones and trifluoroacetic anhydride is reported. Functionally diverse 1-chloro-2,2,2-trifluoroethylidene-substituted pyrrolidones were obtained in moderate to high yields through electrophilic trifluoroacetylation, nucleophilic chlorination, and elimination. This procedure has a wide scope, good functional-group tolerance and the reaction conditions are amenable to scale up. Additionally the obtained 1-chloro-2,2,2-trifluoroethylidene products can be applied to further functionalization as trifluoromethyl-containing building blocks. Some of the title compounds showed fungicidal activity against cucumber downy mildew (CDM). (Figure presented.).

Mild and Efficient Cobalt-Catalyzed Cross-Coupling of Aliphatic Amides and Aryl Iodides in Water

Tan, Bryan Yong-Hao,Teo, Yong-Chua

supporting information, p. 1697 - 1701 (2015/07/20)

A convenient protocol for the C-N cross-coupling of aliphatic amides and iodobenzene is demonstrated using a simple and inexpensive Co(C2O4)·2H2O/N,N′-dimethylethylenediamine (DMEDA) catalytic system in water. Good yields of N-arylated products were isolated (up to 85%) and the protocol has been successfully applied to the synthesis of the anticancer drug, flutamide.

Selective copper-catalyzed N-arylation of lactams with arylboronic acids under base- and ligand-free conditions

Bathini, Thulasiram,Rawat, Vikas Singh,Sreedhar, Bojja

supporting information, p. 1348 - 1351 (2015/06/16)

An oxidative copper-catalyzed cross-coupling of arylboronic acids with various ring-size lactams has been developed. The N-arylated lactams were obtained in moderate to excellent yields without any additional bases, ligands, or additives. This reaction shows complete selectivity for N-arylation of lactams in the presence of a hydroxyl group.

IMIDAZOPYRIDAZINECARBONITRILES USEFUL AS KINASE INHIBITORS

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Page/Page column 96-97, (2010/04/28)

The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The Formula (I) imidazopyridazines inhibit protein kinase activity thereby making them useful as anticancer agents.

CONDENSED HETEROCYCLIC COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY

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Page/Page column 54-55, (2010/04/03)

The present disclosure provides compounds having affinity for the 5-HT6 receptor which are of the formula (I) wherein R1, A, B, D, E, G, Q, Ar, n, m, and p are as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

4'-AMINO CYCLIC COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY

-

Page/Page column 73; 74, (2010/04/06)

The present disclosure provides compounds having affinity for the 5-HT6 receptor which are of the formula (I): formula (I) wherein Cy is selected from formula (Il) and wherein R1, R2, R3, Q, G, Ar, m, n and p are as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

Copper-catalyzed synthesis of benzoxazoles via a regioselective C-H functionalization/C-O bond formation under an air atmosphere

Ueda, Satoshi,Nagasawa, Hideko

supporting information; experimental part, p. 4272 - 4277 (2009/09/08)

(Chemical Equation Presented) An efficient method for the synthesis of functionalized benzoxazoles is described that involves a copper(II)-catalyzed regioselective C-H functionalization/C-O bond formation protocol. The use of dichlorobenzene as a solvent at 160°C allows the use of air as the terminal oxidant in the catalytic synthesis of benzoxazoles in a process that has high functional group tolerance. The presence of a directing group at the meta position markedly improves the reaction efficacy and a variety of 7-substituted benzoxazoles are selectively produced under mild reaction conditions. The mechanism of the reaction is also discussed in this report.

3' SUBSTITUTED COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY

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Page/Page column 92, (2009/04/25)

The present disclosure provides compounds having affinity for the 5-HT6 receptor which are of the formula (I): wherein Q, R1, R4, m and Ar are as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

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