61394-49-8

Usage

Uses

Used in Pharmaceutical Research:
Ethyl 2-oxoindoline-5-carboxylate is used as a building block in organic synthesis and pharmaceutical research, particularly in the development of drugs targeting dopamine receptors in the central nervous system.
Used in Anti-inflammatory Applications:
Ethyl 2-oxoindoline-5-carboxylate has been investigated for its potential anti-inflammatory properties, making it a candidate for the development of anti-inflammatory drugs.
Used in Anticancer Applications:
Ethyl 2-oxoindoline-5-carboxylate has also been investigated for its potential anticancer properties, indicating its potential use in the development of cancer treatments.
Used in Organic Synthesis:
Ethyl 2-oxoindoline-5-carboxylate is used as a versatile starting material in organic synthesis, enabling the creation of a wide range of biologically active compounds.

Upstream product

• 7149-03-3 ethyl 3-bromo-4-aminobenzoate 
• 86400-58-0 5-carbethoxy-2-nitro-phenyl triflate 
• 61394-56-7 ethyl 3-(methylthio)-2-oxindoline-5-carboxylate 
• 86400-59-1 diethyl 5-carbethoxy-2-nitro-benzyl malonate 
• 64-17-5 ethanol 
• 65435-04-3 5-chloroacetylindolin-2-one 
• 59-48-3 2-oxoindole 
• 86400-57-9 3-bromo-4-nitrobenzoic acid ethyl ester 
• 717-01-1 ethyl 3-hydroxy-4-nitro-benzoate 
• 94-09-7 p-aminoethylbenzoate 

Downstream Products

• 86400-60-4 5-carbethoxy-3-benzylidene-indolin-2-one 
• 946135-52-0 1'-(tert-butoxycarbonyl)-2-oxospiro[indoline-3,4'-piperidine]-5-carboxylic acid 
• 86400-62-6 5-carboxy-3-benzyl-indolin-2-one 
• 612487-61-3 5-(hydroxymethyl)-1,3-dihydro-2H-indol-2-one 

Relevant academic research and scientific papers

An efficient synthesis of a spirocyclic oxindole analogue

An efficient, scaleable synthesis approach towards the spirocyclic oxindole analogue 1′-(tert-butoxycarbonyl)-2-oxospiro[indoline-3,4′- piperidine]-5-carboxylic acid (1) is described. The key steps are dianion alkylation and cyclization of ethyl 2-oxindoline-5-carboxylate (4) and demethylation of the resulting spirocyclic oxindole ethyl 1′-methyl-2- oxospiro[indoline-3,4′-piperidine]-5-carboxylate (5). The target compound was obtained in an overall yield of 35 % over eight steps without resorting to chromatographic purification.

Dihydroindolone compounds, a process for their preparation and pharmaceutical compositions containing them

Compounds of formula (I): wherein: m and n represent 1 or 2,A represents a pyrrolyl group,X represents a C(O), S(O) or SO2 group,R1 and R2 represent an alkyl group or, together with the nitrogen atom carrying them, form a heterocyclic group,R3 and R4, together with the atoms carrying them, form a heterocyclic group,R5 represents a hydrogen atom or an alkyl group,R6 represents a hydrogen atom or a halogen atom. Medicinal products containing the same which are useful in treating cancer.