614-05-1 Usage
Uses
Used in Pharmaceutical and Chemical Research:
OXYTHIAMINE HYDROCHLORIDE is used as a reference standard for calibration curve generation in liquid chromatography-tandem mass spectrometry (LC-MS/MS) for oxythiamine pyrophosphate (OTPP) quantification in red blood cells. This application is crucial for accurate measurement and analysis of thiamine levels in biological samples, which can be used to diagnose and monitor thiamine deficiency and related conditions.
Used in Cellular Research:
OXYTHIAMINE HYDROCHLORIDE is used as a thiamine transport inhibitor in human mammary epithelial cells (HMEC) and breast cancer cell lines. This application helps researchers study the role of thiamine transport in the growth and proliferation of cancer cells, as well as the potential therapeutic effects of inhibiting thiamine transport in cancer treatment.
Used in Chemical Synthesis:
OXYTHIAMINE HYDROCHLORIDE is used in the synthesis of oxythiamine picrolonate salt. OXYTHIAMINE HYDROCHLORIDE can be further utilized in various applications, such as pharmaceutical formulations or as an intermediate in the synthesis of other thiamine-related compounds.
Biochem/physiol Actions
Oxythiamine (OT) is a thiamine antagonist. It is a transketolase inhibitor and is employed to study anti-metastatic mechanisms, especially those involving metalloproteinases (MMP). It significantly sensitizes human hepatocellular carcinoma cells (HCC) to sorafenib, favoring tumor suppression.
Check Digit Verification of cas no
The CAS Registry Mumber 614-05-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,1 and 4 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 614-05:
(5*6)+(4*1)+(3*4)+(2*0)+(1*5)=51
51 % 10 = 1
So 614-05-1 is a valid CAS Registry Number.
InChI:InChI=1/C12H15N3O2S.2ClH/c1-8-11(3-4-16)18-7-15(8)6-10-5-13-9(2)14-12(10)17;;/h5,7,16H,3-4,6H2,1-2H3;2*1H
