698-30-6

Basic information

• Product Name: 5-(HYDROXYMETHYL)-2-METHYLPYRIMIDIN-4-OL
• Synonyms: 5-(HYDROXYMETHYL)-2-METHYLPYRIMIDIN-4-OL;4(1H)-Pyrimidinone, 5-(hydroxymethyl)-2-methyl- (9CI);5-(hydroxymethyl)-2-methylpyrimidin-4(1H)-one;4(1H)-Pyrimidinone, 5-(hydroxymethyl)-2-methyl-;5-(hydroxymethyl)-2-methylpyrimidin-4(3H)-one;5-(hydroxymethyl)-2-4(3h)-pyrimidinone;-2-methylpyrimidin-4(1H)
• CAS NO: 698-30-6
• Molecular Formula: C₆H₈N₂O₂
• Molecular Weight: 140.13992
• Product Categories: PYRIMIDINE
• Mol File: 698-30-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 308.984 °C at 760 mmHg
• Flash Point: 140.669 °C
• Appearance: /
• Density: 1.342 g/cm³
• CAS DataBase Reference: 5-(HYDROXYMETHYL)-2-METHYLPYRIMIDIN-4-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(HYDROXYMETHYL)-2-METHYLPYRIMIDIN-4-OL(698-30-6)
• EPA Substance Registry System: 5-(HYDROXYMETHYL)-2-METHYLPYRIMIDIN-4-OL(698-30-6)

Safety Data

• Hazardous Substances Data: 698-30-6(Hazardous Substances Data)

Usage

General Description

5-(Hydroxymethyl)-2-methylpyrimidin-4-ol is a chemical compound with a molecular formula C6H8N2O2. It is a pyrimidine derivative that contains a hydroxymethyl group at the 5th position and a methyl group at the 2nd position of the pyrimidine ring. It is commonly used as a precursor in the synthesis of nucleoside analogs, which have potential applications in pharmaceuticals and antiviral drugs. 5-(HYDROXYMETHYL)-2-METHYLPYRIMIDIN-4-OL may also have biological activity, and further research is being conducted to explore its potential therapeutic properties. Additionally, it is an important intermediate in the synthesis of other organic compounds, making it a valuable building block in chemical and pharmaceutical industries.

Upstream product

• 1749-72-0 5-aminomethyl-2-methyl-3H-pyrimidin-4-one 
• 5353-05-9 (2-methyl-6-oxo-1,6-dihydro-pyrimidin-5-yl)-acetic acid amide 
• 14273-42-8 (2-methyl-6-oxo-1,6-dihydro-pyrimidin-5-yl)-acetic acid ethyl ester 
• 412035-23-5 (2-methyl-6-oxo-1,6-dihydro-pyrimidin-5-yl)-acetic acid hydrazide 
• 412035-72-4 (2-methyl-6-oxo-1,6-dihydro-pyrimidin-5-ylmethyl)-carbamic acid ethyl ester 
• 53135-24-3 ethyl 4-hydroxy-2-methylpyrimidine-5-carboxylate 

Downstream Products

• 731766-78-2 4-chloro-5-chloromethyl-2-methyl-pyrimidine 
• 135-94-4 4-Methylamino-2-methyl-5-hydroxymethyl-pyrimidin 
• 92-35-3 thiochrome 
• 614-05-1 oxythiamine chloride hydrochloride 
• 117026-52-5 5-(2-hydroxy-ethyl)-4-methyl-3-(2-methyl-6-oxo-1,6-dihydro-pyrimidin-5-ylmethyl)-thiazolium; bis-(4-phenylazo-benzenesulfonate ) 
• 123965-06-0 5-(2-hydroxy-ethyl)-4-methyl-3-(2-methyl-6-oxo-1,6-dihydro-pyrimidin-5-ylmethyl)-thiazolium; [4-(4-dimethylamino-phenylazo)-benzenesulfonate ] 

Relevant articles and documents

Thiamine Biosynthesis in Yeast - Evaluation of 4-Hydroxy-5-hydroxymethyl-2-methylpyrimidine as a Precursor

The putative role of 4-hydroxy-5-hydroxymethyl-2-methylpyrimidine 2 as a late precursor in the biosynthesis of thiamine 1 by Saccharomyces cerevisiae has been examined using the deuteriated derivative 2a.To enable measurement of deuterium incorporation into the pyrimidine ring fragment of 1, a procedure for the degradation of 1 to the aniline derivative 6 using thiaminase I from Bacillus thiaminolyticus has been developed.While 4-amino-2-methyl-5-hydroxymethylpyrimidine 3a was incorporated into thiamine, deuterium from hydroxy-pyrimidine 2a was not incorporated to any significant extent, indicating that amination of compound 2 is not a late step in the biosynthesis of the pyrimidine ring.