6141-26-0

Usage

InChI:InChI=1/C17H18N2O4S/c1-2-3-10-23-16(21)12-6-8-13(9-7-12)18-17(24)19-15(20)14-5-4-11-22-14/h4-9,11H,2-3,10H2,1H3,(H2,18,19,20,24)

Upstream product

• 551-93-9 2-aminoacetophenone 
• 407-25-0 trifluoroacetic anhydride 
• 19165-29-8 N-(trifluoroacetyl)anthranilic acid 
• 75-16-1 methylmagnesium bromide 
• 52670-38-9 2-ethynylaniline 

Downstream Products

• 83842-55-1 2‐(trifluoromethyl)quinolin‐4(1H)‐one 
• 1609487-74-2 C₁₂H₁₀F₃NO₂ 
• 140674-74-4 4-Methyl-9-(o-trifluoroacetylaminophenyl)-5,8-diazadeca-3,8-dien-2-one 
• 1344732-99-5 C₂₅H₁₉F₃N₆O 

Relevant academic research and scientific papers

Unveiling reactive metal sites in a Pd pincer MOF: Insights into Lewis acid and pore selective catalysis

A porous Zr metal-organic framework, 1-PdBF4 [Zr6O4(OH)4(OAc)2.4{(PNNNP)Pd(MeCN)}2.4(BF4)2.4; PNNNP = 2,6-(HNPAr2)2C5H3N; Ar = p-C6H4CO2-], has been synthesized via postsynthetic oxidative I-/BF4- ligand exchange using NOBF4. 1-PdBF4 enjoys markedly superior catalytic activity and recyclability to its trifluoracetate-exchanged analogue, 1-PdTFA, for the intramolecular cyclization of o-alkynyl anilines and the carbonyl-ene cyclization of citronellal. Moreover, 1-PdBF4 demonstrates a rare example of pore selective catalysis for the cyclization of 2-ethynyl aniline.

Palladium-catalyzed tandem intramolecular oxy/amino-palladation/isocyanide insertion: Synthesis of α-benzofuranyl/indolylacetamides

A novel palladium-catalyzed approach to 2-benzofuranyl/indolylacetamides from 1-(o-hydroxy/aminophenyl)propargylic alcohols and isocyanides is described. The reaction proceeds through a cascade that includes oxy/aminopalladation, isocyanide insertion, and 1,4-hydroxyl migration. No oxidant or ligand is needed to promote the cascade, and the reactions are carried out under mild conditions to afford the products through high functional tolerance.

The reaction of o-amino aryl carboxylic acids with Grignard reagents. The unusual effect of the N-protecting group on aryl ketone formation

The addition of Grignard reagents to the o-amino aryl carboxylic acids without any additive forms the tertiary carbinol as a major product. Unexpectedly, the aryl ketones are formed as the only isolated product if o-amino moiety of anthranilic acids is protected with Boc, trifluoroacetyl, and pivaloyl protecting groups.

N-Alkylated 2-trifluoromethyl-4-quinolones by addition of base and an alkylating agent to 2-trifluoroacetylaminoacetophenones

2-Trifluoroacetylaminoacetophenones 1 are cyclized to N-alkyl-2-trifluoromethyl-4-quinolones 2 in one pot with concomitant N-alkylation in 40 to 74% yield using potassium hydroxide in acetone containing an alkylating agent.