61416-34-0

Usage

Preparation

Also obtained by treatment of a-bromo-3,4-dimethoxyacetophenone with hexamethylenetetramine in chloroform at r.t. for 1 h.

InChI:InChI=1/C10H13NO3.ClH/c1-13-9-4-3-7(8(12)6-11)5-10(9)14-2;/h3-5H,6,11H2,1-2H3;1H

Upstream product

• 100-97-0 hexamethylenetetramine 
• 1835-02-5 2-Bromo-1-(3,4-dimethoxyphenyl)ethanone 
• 871902-52-2 N-(3,4-dimethoxy-phenacyl)-phthalamic acid 
• 1131-62-0 1-(3,4-dimethoxyphenyl)ethanone 

Downstream Products

• 90253-94-4 2-(Isobutyrylamino)-3',4'-dimethoxyacetophenon 
• 877387-19-4 C₂₀H₂₂N₂O₆ 
• 877386-95-3 C₃₀H₃₃N₃O₁₀ 
• 5190-84-1 2-(Acetylamino)-3',4'-dimethoxyacetophenon 
• 932750-20-4 5-amino-1-cyclopentyl-N-[2-(3,4-dimethoxyphenyl)-2-oxoethyl]-3-ethyl-1H-pyrazole-4-carboxamide 
• 90253-91-1 7-(3,4-Dimethoxybenzoyl)-5-isopropyl-2-phenyl-1H,7H-s-triazolo<1,2-a>-s-triazol-1,3(2H)-dion 
• 90253-95-5 5-(3,4-Dimethoxyphenyl)-2-isopropyloxazol 

Relevant academic research and scientific papers

Synthesis of 2-Amino Substituted Oxazoles from α-Amino Ketones and Isothiocyanates via Sequential Addition and I2-Mediated Desulfurative Cyclization

Oxazol-2-amines were synthesized by annulation of α-amino ketones and isothiocyanates. This sequential synthetic process involves addition of α-amino ketones to isothiocyanates and I2-promoted desulfurative cyclization omitting isolation of the less stable thiourea intermediates. It is transition metal-free and operationally simple, providing access to a variety of 2-amino substituted oxazole derivatives under mild reaction conditions. (Figure presented.).

Synthesis and biological evaluation of imidazol-2-one derivatives as potential antitumor agents

A new series of aryl substituted imidazol-2-one derivatives structurally related to combretastatin A-4 (CA-4) were synthesized and evaluated for their cytotoxic activities in vitro against various human cancer cell lines including MDR cell line. The cytotoxic effects of compounds 7b and 7i proved to be similar to or greater than that of docetaxel. The highly active compound 7b also exhibited excellent inhibitory activity on tumor growth in vivo.

NOVEL 5,6-DIHYDROPYRAZOLO[3,4-E] [L,4]DIAZEPIN-4 (IH) -ONE DERIVATIVES FOR THE TREATMENT OF ASTHMA AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE.

The present invention provides a compound of a formula (I): wherein the variables are defined herein; to a process for preparing such a compound; and to the use of such a compound in the treatment of a PDE 4 mediated disease state.