6143-71-1

Basic information

• Product Name: N-(dimethylamino-phenyl-phosphanyl)-N-methyl-methanamine
• CAS NO: 6143-71-1
• Molecular Formula: C₁₀H₁₇N₂P
• Molecular Weight: 196.232
• Mol File: 6143-71-1.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 266.2°Cat760mmHg
• Flash Point: 114.8°C
• Density: g/cm³
• CAS DataBase Reference: N-(dimethylamino-phenyl-phosphanyl)-N-methyl-methanamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(dimethylamino-phenyl-phosphanyl)-N-methyl-methanamine(6143-71-1)
• EPA Substance Registry System: N-(dimethylamino-phenyl-phosphanyl)-N-methyl-methanamine(6143-71-1)

Safety Data

• Hazardous Substances Data: 6143-71-1(Hazardous Substances Data)

Upstream product

• 3348-44-5 bis(N,N-dimethylamino)chlorophosphine 
• 591-51-5 phenyllithium 
• 108-86-1 bromobenzene 
• 644-97-3 Dichlorophenylphosphine 
• 124-40-3 dimethyl amine 
• 1073-47-8 phenyldibromophosphine 

Downstream Products

• 7238-02-0 C₁₂H₁₇N₂PS₄ 
• 55983-39-6 2,7-dimethyl-5-phenyl-1,4,6,9-tetraoxa-5λ⁵-phospha-spiro[4.4]nonane 
• 55983-40-9 5-Phenyloctamethyl-1,4,6,9-tetraoxa-5-phosphaspiro<4.4>nonane 
• 708-96-3 phenyl-phosphonous acid ethyl ester-dimethylamide 
• 55215-27-5 C₁₁H₂₀N₃P 
• 34736-73-7 5-phenyl-1,4,6,9-tetraoxa-5-phosphaspiro<4.4>nonane 
• 22834-12-4 C₁₀H₁₇N₂PTe 
• 131369-85-2 dimethylamino(dimethylamino-4-methoxyphenylthiophosphorylthio)-phenylphosphine 
• 131369-97-6 Bis(dimethylamino-4-methoxyphenylthiophosphorylthio)phenylphosphin 
• 1885-79-6 2-phenyl-3-methyl-1,3,2-oxazaphospholidine 
• 92120-29-1 N-t-butyl-phenyl-2-dioxazaphosphocanne-1,3,6,2 
• 211565-44-5 (-)-(2R,4R,5S)-2-phenyl-3,4-dimethyl-5-phenyl-1,3,2-oxazaphospholidine-2-oxide 
• 87214-07-1 (2R,4S,5R)-2,3,4,5-tetrahydro-3,4-dimethyl-2,5-diphenyl-1,3,2-oxazaphosphole 
• 87214-07-1 (2S,4S,5R)-3,4-Dimethyl-2,5-diphenyl-1,3,2-oxazaphospholidin 

Relevant articles and documents

Iridium-Triggered Allylcarbamate Uncaging in Living Cells

Designing a metal catalyst that addresses the major issues of solubility, stability, toxicity, cell uptake, and reactivity within complex biological milieu for bioorthogonal controlled transformation reactions is a highly formidable challenge. Herein, we report an organoiridium complex that is nontoxic and capable of the uncaging of allyloxycarbonyl-protected amines under biologically relevant conditions and within living cells. The potential applications of this uncaging chemistry have been demonstrated by the generation of diagnostic and therapeutic agents upon the activation of profluorophore and prodrug in a controlled fashion within HeLa cells, providing a valuable tool for numerous potential biological and therapeutic applications.

Highly efficient phosphapalladacyclic catalysts for the hydroarylation of norbornene

Exceptionally high turnover numbers of up to 196 x 106 moles of product per mole of catalyst, turnover frequencies of up to 12 x 106 moles of product per mole of catalyst per hour, and yields of 98% were achieved in the hydroarylatio

Asymmetric synthesis of (S,S)-(+)-1,1′-bis-(methyl-phenyl-phosphino) ferrocene

The asymmetric synthesis of 1,1′-bis-(methyl-phenyl-phosphino) ferrocene 1 is described using the oxazaphospholidine borane complex 5 as synthon. Two strategies were investigated, based either on P-C bond formation by ring opening of complex 5 with the 1,1′-dilithio ferrocene 10, or on homocoupling of the cyclopentadienyl-methyl-phenyl-phosphine borane 2 anion with FeCl2. The first leads to a diastereomeric mixture of the diphosphine 1 in a 55:45 ratio, and the low stereoselectivity is explained by the steric hindrance of the ferrocene dianion. In the second strategy, the (R)-cyclopentadienyl phosphine borane 2 (85% ee) was prepared by the reaction of CpNa with the optically active chlorophosphine borane 14, derived from the aminophosphine borane 6a. The coupling of 2 leads to the 1,1′-diphosphino ferrocene borane 13, which is obtained diastereomerically pure by recrystallization, then decomplexed to the corresponding (S,S)-diphosphine 1.